David Schneider
Academic Appointments
- Associate Professor, Microbiology & Immunology
Key Documents
Contact Information
- Academic Offices
Personal Information Email Tel (650) 724-8064
Professional Overview
Honors and Awards
- NIH Director's Pioneer Award, NIH (2011)
- Senior Scholar Award in Aging, Ellison Medical Foundation (2008-12)
- New Scholar in Global Infectious Disease, Ellison Medical Foundation (2002-6)
- Larry Sandler Award Memorial Award for best Drosophila thesis, Genetics Society of America (1993)
Professional Education
| Ph.D.: | University of California, Berkeley, Molecular Biology (1992) |
| B.Sc.: | University of Toronto, Biochemistry (1986) |
Postdoctoral Advisees
Adler Dillman, Karla Lightfield, Jose Maia Campos de Oliveira, Kyung Han Song, Damian Trujillo
Graduate & Fellowship Program Affiliations
Internet Links
Scientific Focus
Current Research Interests
We study innate immunity and microbial pathogenesis. We have been studying models for a variety of bacterial infections including: Listeria, Mycobacteria, Salmonella and Streptococcus as well as some fungi, malaria and viruses. Our current focus is to determine how we recover from infections.
We are using a new approach to study the outcome of infections. We are starting by plotting health by microbe number over the course of infections. This produces characteristic phase plots that we think can be used to predict the outcome of infections and to define appropriate treatments. We like to assess "health" in whole animals rather than in vitro but we use a large range of tools ranging from genetics, to microarray analyses to flow cytometry.
We focus on two models. We recently started working on a mouse model for malaria in which we follow the progress of a Plasmodium chabaudi infection. We are making extremely mutlivariate plots of the disease process. Our goal is to define "biovectors" that predict the outcome of infection and to identify the physiological mechanisms required for recovery from infections.
We continue to work on fruit flies as a model for microbial pathogenesis. Here we take advantage of the spectacularly deep genetic tools available to Drosophila geneticists to discover mechanisms involved in pathogenesis and the recovery from infections.
Publications
- Tracing personalized health curves during infections. PLoS Biol. 2011; (9): e1001158
- The role of anorexia in resistance and tolerance to infections in Drosophila. PLoS Biol. 2009; (7): e1000150
- Balancing resistance and infection tolerance through metabolic means. Proc Natl Acad Sci U S A. 2012; (35): 13886-7
- Disease tolerance as a defense strategy. Science. 2012; (6071): 936-41
- How the fly balances its ability to combat different pathogens. PLoS Pathog. 2012; (12): e1002970
- Immunity in society: diverse solutions to common problems. PLoS Biol. 2012; (4): e1001297
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