Gary K. Steinberg, MD, PhD
Academic Appointments
- Professor, Neurosurgery
- Member, Bio-X
- Professor (By courtesy), Neurology & Neurological Sciences
Key Documents
Contact Information
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Clinical Offices
Neurosurgery 300 Pasteur Dr R301A MC 5325 Stanford, CA 94305 Tel Work (650) 723-5575 Fax (650) 725-0390Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
- Academic Offices
Personal Information Email Tel (650) 723-5575Alternate Contact Tristy Tara Administrative Associate Email Tel Work (650) 725-5562Not for medical emergencies or patient use
Professional Overview
Clinical Focus
- Cerebrovascular and Spinal Vascular Surgery
- Intracranial Aneurysms
- Intracranial/Intraspinal AVMs, AV fistulas, Cavernous Malformations
- Moyamoya Disease and Occlusive Cerebrovascular Disease
- Carotid Endarterectomy
- Neurosurgery
Administrative Appointments
- Chair, Stanford University School of Medicine - Neurosurgery (1995 - present)
Professional Education
| Board Certification: | Neurosurgery, American Board of Neurological Surgery (1989) |
| Board Certification: | Neurological Surgery, American Board of Neurological Surgery (1989) |
| Residency: | Santa Clara Valley Medical Center, CA USA (1986) |
| Fellowship: | Institute Of Neurology, England (1981) |
| Medical Education: | Stanford University School of Medicine CA (1980) |
Scientific Focus
Current Research Interests
Our laboratory is interested in elucidating the pathophysiology of acute cerebral ischemia and in developing neuroprotective treatments, as well as methods to restore neurologic function after stroke. Using rodent wild type, knock out and transgenic models of focal and global ischemia, we are investigating the physiologic processes leading from decreased blood flow after arterial occlusion to irreversible brain injury. A major focus of our work concerns the role of oxidative stress, inflammation and gene expression on necrotic and apoptotic mechnisms of ischemic cell death. Alterations in cerebral blood flow, neuronal metabolic activity, electrophysiology, and gene/protein expression are examined in relation to neurologic behavior. We are also studying the brain microenvironment during recovery after stroke and the effects of stem cell transplantation and enhanced neurogenesis in promoting recovery of function.
We have been successful in attenuating ischemic cerebral damage by inducing mild brain hypothermia (30-33 degrees C) or overexpression of various genes (glucose transporter, bcl-2, hsp70, calbindin, catalase, glutathione peroxidase, SOD) either before or after stroke. Transplantation of human neural stem cells after experimental stroke results in survival, targeted migration and differentiation into appropriate neuronal and glial cell types, while anti-inflammatory treatment enhances native neurogenesis and gliagenesis following stroke.
Methodologies utilized in the laboratory include microsurgery, light and confocal microscopy, stereology, molecular biology techniques, autoradiography, magnetic resonance imaging, electrophysiology, cerebral blood flow measurements and gene transfer therapy.
Our clinical research efforts focus on novel approaches for treating intracranial aneurysms, intracranial and spinal vascular malformations, occlusive cerebrovascular disease such as Moyamoya disease and stroke. These include advances in microsurgery, interventional neuroradiology, stereotactic radiosurgery, 3D imaging, surgical navigation, revascularization techniques, the use of mild brain hypothermia and other clinical neuroprotective agents, and neurotransplantation.
Publications
- Cavernous malformation of brainstem, thalamus, and Basal Ganglia: a series of 176 patients. Neurosurgery. 2013; (4): 573-89; discussion 588-9
- Multimodality management of Spetzler-Martin Grade III arteriovenous malformations. J Neurosurg. 2012; (6): 1279-88
- Arterial spin-labeling MRI can identify the presence and intensity of collateral perfusion in patients with moyamoya disease. Stroke. 2011; (9): 2485-91
- Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain. Brain. 2011; (Pt 6): 1777-89
- Intraoperative blood flow analysis of direct revascularization procedures in patients with moyamoya disease. J Cereb Blood Flow Metab. 2011; (1): 262-74
- Management of pediatric intracranial arteriovenous malformations: experience with multimodality therapy. Neurosurgery. 2011; (3): 540-56; discussion 556
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