Eugene Bauer
Academic Appointments
- Emeritus Faculty, Acad Council, Dermatology
Key Documents
Contact Information
- Academic Offices
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Scientific Focus
Current Research Interests
The three areas of research are:
(1) defining the role of matrix metalloproteinases (MMPs) in connective tissue remodeling of the skin;
(2) defining the macromolecular structures and their interactions in the cutaneous basement membrane zone (BMZ); and
(3) developing methods for delivery of extracutaneous gene therapy in epidermolysis bullosa.
Matrix metalloproteinases are pivotal enzymes in connective tissue remodeling. The events in signal transduction that govern MMP expression and activity and expression of inhibitory proteins are crucial for understanding wound healing, tumorigenesis, and certain genetic diseases.
The cutaneous BMZ is a complex structure at the interface of the epidermis and dermis. The synthesis, secretion and organization of macromolecules of the BMZ involve regulatory events that dictate integrity of the skin, that are crucial for wound healing, and that can be aberrant in genetic diseases. Our laboratory focuses on discovery, cloning, sequencing, and creating gene therapy approaches for patients with hereditary forms of epidermolysis bullosa, a serious (potentially lethal) skin disease.
Publications
- Skin biology. Dermatol Ther. 2011 Sep-Oct; (5): 464-70
- Dermatology; the importance of the intellectual base of the specialty. Arch Dermatol. 2000; (1): 24
- Gene therapy for a lethal genetic blistering disease: a status report. Trans Am Clin Climatol Assoc. 1999: 86-92
- Two-photon excitation of 4'-hydroxymethyl-4,5',8-trimethylpsoralen. Photochem Photobiol. 1997; (1): 91-5
- Inhibition of collagenase type I expression by psoralen antisense oligonucleotides in dermal fibroblasts. FASEB J. 1995; (13): 1371-7
- The assembly of laminin-5 subunits. J Biol Chem. 1995; (40): 23496-503
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