Xiaoyuan (Shawn) Chen
Academic Appointments
- Member, Stanford Cancer Institute
- Member, Bio-X
Key Documents
Contact Information
- Academic Offices
Alternate Contact Susan Singh Administrative Associate Email Tel Work 650-736-9781
Professional Overview
Administrative Appointments
- Section Editor, Amino Acids (2010 - present)
- Topical Editor, Nanoscale Research Letters (2008 - present)
- Editorial Board, European Journal of Nuclear Medicine and Molecular Imaging (2008 - present)
- Editorial Board, J Nucl Med (2008 - present)
- Editorial Board, Bioconjugate Chemistry (2008 - present)
- Editorial Board, Molecular Imaging (2008 - present)
Honors and Awards
- Best Basic Science paper, J Nucl Med (2008)
- Best Basic Science Awards, SNM Annual Meetings (2006, 2007, 2008)
- First place award, SNMs Molecular Imaging Center of Excellence (2008)
Graduate & Fellowship Program Affiliations
Internet Links
Scientific Focus
Current Research Interests
We are interested in developing and validating novel molecular imaging probes (nanoparticles, antibodies, proteins, peptides and small organic molecules) for the visualization and quantification of molecular targets that are aberrantly expressed during tumor growth, angiogenesis and metastasis. We are trying to combine both anatomical and molecular imaging techniques to pinpoint molecular and functional information related to tumor growth and dissemination, and monitor specific molecular therapeutic efficacy. We are currently working closely with two important angiogenesis targets: integrin alpha(v)beta(3) and vascular endothelial growth factor receptor subtype-2 (VEGFR-2). Integrins expressed on endothelial cells modulate cell migration and survival during angiogenesis. Integrins expressed on carcinoma cells potentiate metastasis by facilitating invasion and movement across blood vessels. In several malignancies, tumor expression of integrin alpha(v)beta(3) correlates well with tumor progression. VEGF is a key regulator of tumor angiogenesis and is the most potent endothelial cell mitogen. Binding of VEGF to its receptor on the endothelial cell membrane stimulates the VEGF signaling pathway. VEGFR-2 (KDR/Flk-1) is the primary VEGF receptor on endothelial cells. Specific projects include nanoplatform-based molecular imaging, multimodality imaging of angiogenesis and metastasis, as well as targeted delivery of gene, chemo, and radiotherapeutics.
Publications
- Characterization of Angiogenesis in GL26 Murine-Derived Glioblastoma Multiforme Neurological Res. in press
- Multimodality Molecular Imaging of Tumor Angiogenesis J Nucl Med. in press
- Phage display peptide probes for imaging early response to bevacizumab treatment. Amino Acids. 2011; (5): 1103-12
- 18F-labeled galacto and PEGylated RGD dimers for PET imaging of αvβ3 integrin expression. Mol Imaging Biol. 2010; (5): 530-8
- Cetuximab-based immunotherapy and radioimmunotherapy of head and neck squamous cell carcinoma. Clin Cancer Res. 2010; (7): 2095-105
- Firefly luciferase-based dynamic bioluminescence imaging: a noninvasive technique to assess tumor angiogenesis. Neurosurgery. 2010; (4): 751-7; discussion 757
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