Katrin Chua
Academic Appointments
- Associate Professor, Medicine - Endocrinology, Gerontology, & Metabolism
- Member, Stanford Cancer Institute
- Member, Bio-X
Key Documents
Contact Information
- Academic Offices
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Professional Overview
Honors and Awards
- Ellison Medical Foundation New Scholar in Aging, Ellison Medical Foundation/AFAR (2008-2012)
- Paul Beeson Scholar in Aging Research, National Institute on Aging/American Federation for Aging Research (2006-)
- Pfizer Postdoctoral Fellow in Rheumatology/Immunology, Pfizer (2002-2005)
- Fellow of the Jane Coffin Childs Memorial Fund For Medical Research, Jane Coffin Childs Memorial Fund For Medical Research (2001-2002)
- Sackler Scholar in Psychobiology, Harvard University (1995-1996)
Professional Education
| Ph.D.: | Harvard Medical School, Neuroscience/Cell Biology (2001) |
| M.D.: | Harvard Medical School, Medicine (2001) |
| B.A.: | Harvard University, Biochemistry/Molecular Biology (1991) |
Graduate & Fellowship Program Affiliations
Internet Links
Scientific Focus
Current Research Interests
Our lab is interested in understanding molecular processes that underlie aging and age-associated pathologies in mammals. We focus on a family of genes, the SIRTs, which regulate stress resistance and lifespan in lower organisms such as yeast, worms, and flies. In mammals, we recently uncovered a number of ways in which SIRT factors may contribute to cellular and organismal aging by regulating resistance to various forms of stress. We have now begun to characterize the molecular mechanisms by which these SIRT factors function. In particular, we are interested in how SIRT factors regulate chromatin, the molecular structure in which the DNA of mammalian genomes is packaged, and how such functions may link genome maintenance to stress resistance and aging.
Publications
- Cancer: Metabolism in 'the driver's seat. Nature. 2012; (7429): 362-3
- SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Nature. 2012; (7405): 114-8
- SIRT6 is required for maintenance of telomere position effect in human cells. Nat Commun. 2011: 433
- SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell. 2009; (1): 62-74
- SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature. 2008; (7186): 492-6
- A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation. Mol Cell. 2013; (3): 444-56
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