Department: Radiology

Keywords: Tumor Imaging, Contrast Agents, Cancer imaging, MR imaging, Radiology I am interested in and involved with novel approaches for Tumor MR Imaging, with an emphasis on the development and evaluation of cell-specific contrast agents. For example, I have utilized superparamagnetic iron oxide nanoparticles (USPIO's) to visualize tumor associated macrophages (TAMs). TAMs are of importance because they correlate strongly with poor outcome in patients with breast cancer and other cancers b..

Advanced imaging, including magnetic resonance imaging, of injury to the developing central nervous system; including fetal, neonatal, infant and young child; and, including nonaccidental injury (e.g. child abuse).

Magnetic Resonance Imaging and Sonographic diagnosis of fetal anomalies. Focus interest in the diagnosis and conservative (non-surgical and minimal radiation) management of congenital broncho pulmonary malformations. Imaging of appendicitis in children. Sonography of the pediatric testis.

Applications of computer graphics to medical imaging, with emphasis on diagnosis of bowel pathology using virtual colonoscopy. Dynamic joint imaging with open Magnetic Resonance Imaging system.

Chronic pain sufferers are unfortunately limited by poor diagnostic tests and therapies. Our lab is interested in 'imaging pain' by using multimodality molecular imaging techniques to study nociception and neuronal inflammation as a means of improving objective, image-guided diagnosis and treatment of chronic pain disorders. We develop new molecular contrast agents for use in positron emission tomography (PET) and magnetic resonance imaging (MRI), working towards eventual clincal translation.

Studies on apoptotic cell death in vivo using the H MRS phenomenon.

Cardiac differentiation of human induced pluripotent stem cells using developmental biology paradigms, chemically defined reprogramming, culture, and differentiation, disease modeling, cardiotoxicity, electrophysiology

To develop novel molecular imaging probes and techniques for non-invasively early detection of cancer using multimodality imaging technologies including PET, SPECT, MRI, optical imaging, etc.

(1) development of new chemical probes for studying biological problems in human health and disease, (2) method for fast and specific post-synthesis modification of DNA and its further applications for, e.g. aptamer selection and array analysis (3) borononic acid-based lectin mimics (5) drug design, synthesis and biological evaluation

Our group's primary objectives are: 1) Novel radioligand and radiotracer development. We will develop novel PET (Positron Emission Tomography) imaging agents with MIPS and Stanford faculty as well as other outside collaborations including academia and pharmaceutical industry. Although my personal research interests will be to discover and design of candidate probes that target molecular targets in the brain, our group focus will primarily be on cancer biology and gene therapy. In conjuncti..

Noninvasive oxygenation measurement with MRI MRI relaxometry Numerical simulation 19F MRI

We develop and use the tools of molecular imaging to understand oncogenesis, reveal patterns of cell migration in immunosurveillance, monitor gene expression, visualize stem cell biology, and assess the distribution of pathogens in living animal models of human biology and disease. Biology doesn't occur in "a vacuum" or on coated plates--it occurs in the living body and that's were we look for biological patterns and responses to insult.

Our Research Group develops non-invasive cellular imaging techniques that can generate detailed information about specific cell populations in the body. The ultimate goal of this research is to determine tumor characteristics which are linked to poor prognosis, to develop, direct and monitor related targeted therapies and to monitor stem cell therapies that regenerate physiologic cell populations. We have a strong focus on translational, bench-to-bedside research.

1. MRI of Breast Cancer, particularly new techniques. Currently being explored are techniques including ultra high spatial resolution MRI and contrast-agent-free detection of breast tumors. 2. MRI-guided interventions, especially MRI-guided cryosurgery of prostate cancer

Imaging of gastrointestinal tract cancer Ultrasound Simulated learning environment

Dr. Dodd is involved in clinical trials using endovascular coils that have a fiber coating that help heal aneurysms of the neck and can prevent an aneurysm from reforming. He uses minimally invasive endoscopic techniques to treat brain tumors. Dodd's research interests are in cerebral blood vessel reactivity and stroke.

Dr. Ertosun graduated from Bilkent Üniversitesi (Bilkent University) with a B.S. degree in Electrical & Electronics Engineering in 2004. During his undergraduate studies at Bilkent, he conducted research with Prof. Haldun Ozaktas in the fields of optics and signal processing. He received an M.S. degree in Electrical Engineering from Stanford University in 2006, where his research focused on optoelectronic & semiconductor devices, and carbon nanotubes. He received a second M.S. degree in Financ..