Department: Stanford Cancer Institute
Division: Cancer Biology
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Academic Appointments Professor, Medicine - Hematology
Member, Bio-X
Member, Stanford Cancer Institute
Professor, Biochemistry
Clinical Focus- Cancer > Hematology
- Medical Oncology
Research InterestTelomeres are nucleoprotein complexes that protect chromosome ends and shorten with cell division and aging. We are interested in how telomere shortening influences cancer, stem cell function and genomic stability. Telomerase is a reverse transcriptase that synthesizes telomere repeats and is expressed in stem cells and in cancer. We have found that telomerase also regulates stem cells and we are pursuing the function of telomerase through diverse genetic and biochemical approaches.
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Academic Appointments Associate Professor, Radiation Oncology - Radiation and Cancer Biology
Member, Stanford Cancer Institute
Member, Bio-X
Associate Professor, Genetics
Research InterestOur research is aimed at defining the pathways of p53-mediated apoptosis and tumor suppression, using a combination of biochemical, cell biological, and mouse genetic approaches. Our strategy is to start by generating hypotheses about p53 mechanisms of action using primary mouse embryo fibroblasts (MEFs), and then to test them using gene targeting technology in the mouse.
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Academic Appointments Professor, Pathology
Member, Bio-X
Member, Stanford Cancer Institute
Research InterestGenetic and cell biological analyses of signals controlling cell polarity and morphogenesis. Frizzled signaling and cytoskeletal organization.
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Academic Appointments Assistant Professor, Developmental Biology
Assistant Professor, Computer Science
Member, Bio-X
Member, Stanford Cancer Institute
Research InterestDr. Bejerano, co-discoverer of ultraconserved elements, studies the Human Genome. Through computation and experimentation we investigate the Systems Biology parts-list of many thousands genomic regions involved in gene transcription regulation during embryonic development. Major interests include (1) the origins and evolution of these regions, (2) how they encode their individual as well as combined roles, (3) their contribute to human disease, and (4) their contribute to species adaptation.
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Academic Appointments Professor, Medicine - Hematology
Member, Stanford Cancer Institute
Member, Bio-X
Clinical Focus- Cancer > Hematology
- Hematology
- Multiple Myeloma
Research InterestRegulation of expression of oncogenes in normal and malignant hematologic cells.
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Academic Appointments Associate Professor, Genetics
Member, Stanford Cancer Institute
Member, Bio-X
Research InterestOur lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two short-lived model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri.
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Academic Appointments Professor, Medicine - Gastroenterology & Hepatology
Member, Stanford Cancer Institute
Clinical Focus- Gastroenterology
- Inflammatory Bowel Diseases
Research InterestMolecular mechanisms of intestinal cell growth control; function and regulation of the Src family of tyrosine kinases in normal cells, and their deregulation in cancer cells.
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Academic Appointments Professor, Dermatology
Member, Stanford Cancer Institute
Member, Bio-X
Clinical Focus- Cancer > Cutaneous (Dermatologic) Oncology
- Dermatology
- General Dermatology
Research InterestOur research is focused on how the activities of hundreds or even thousands of genes (gene parties) are coordinated to achieve biological meaning. We have pioneered methods to predict, dissect, and control large-scale gene regulatory programs; these methods have provided insights into human development, cancer, and aging.
Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital -
Academic Appointments Assistant Professor, Microbiology & Immunology - Baxter Laboratory
Member, Stanford Cancer Institute
Research InterestWe study the genetic networks controlled by regulatory RNAs, such as microRNAs (miRNAs), and currently focus on two complementary aspects of miRNA biology: (1) The roles of miRNAs in modulating the development, function, and pathogenesis of vertebrate immune systems and (2) the mechanisms by which these regulatory RNAs control gene expression.
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Academic Appointments Associate Professor, Chemical and Systems Biology
Member, Stanford Cancer Institute
Member, Bio-X
Member, Child Health Research Institute
Associate Professor, Developmental Biology
Associate Professor (By courtesy), Natural Sciences Cluster - Chemistry Department
Research InterestOur laboratory combines synthetic chemistry and developmental biology to investigate the molecular events that regulate embryonic patterning, tissue regeneration, and tumorigenesis. We are currently using genetic and small-molecule approaches to study the molecular mechanisms of Hedgehog signaling, and we are developing chemical technologies to perturb and observe the genetic programs that underlie vertebrate development.
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Academic Appointments Associate Professor, Medicine - Endocrinology, Gerontology, & Metabolism
Member, Bio-X
Member, Stanford Cancer Institute
Research InterestOur lab is interested in understanding molecular processes that underlie aging and age-associated pathologies in mammals. We focus on a family of genes, the SIRTs, which regulate stress resistance and lifespan in lower organisms such as yeast, worms, and flies. In mammals, we recently uncovered a number of ways in which SIRT factors may contribute to cellular and organismal aging by regulating resistance to various forms of stress. We have now begun to characterize the molecular mechanisms b..
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Academic Appointments Associate Professor, Chemical and Systems Biology
Member, Bio-X
Member, Stanford Cancer Institute
Associate Professor (By courtesy), Natural Sciences Cluster - Chemistry
Research InterestThe use of genetic, biochemical and chemical approaches to understand the DNA damage-induced cell cycle checkpoints and the processes that contribute to maintenance of genomic stability.
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Academic Appointments Professor, Pathology
Member, Child Health Research Institute
Member, Stanford Cancer Institute
Professor, Pediatrics
Clinical Focus- Pathology Anatomic
- Pathology and Laboratory Medicine
Research InterestThe role of oncoproteins in cancer and development; molecular and cellular biology of hematologic malignancies; targeted molecular therapies of cancer.
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Academic Appointments Professor, Genetics
Member, Bio-X
Member, Stanford Cancer Institute
Professor, Medicine
Research InterestWe study RNA decay and mechanisms that affect microbial antibiotic resistance, as well as the exploitation of host genes by pathogens. A small bioinformatics team within our lab has developed knowledge based systems to aid in investigations of gene expression on a genome-wide basis.
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Academic Appointments Member, Stanford Cancer Institute
Research InterestWe study the molecular and cellular mechanisms that control mitosis and cytokinesis in normal cells and their dysregulations that lead to aneuploidy and genomic instability in tumor cells. The current focus is on the cell cycle regulatory circuits consisting of kinases and ubiquitin ligases. In addition, we investigate the assembly, dynamics and function of mitotic structures. We use a combination of genomics, cell biology, biochemistry, and molecular genetics in mammalian cells.
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Academic Appointments Professor Emeritus, Medicine - Endocrinology, Gerontology, & Metabolism
Emeritus Faculty, Acad Council, Medicine - Endocrinology, Gerontology, & Metabolism
Member, Stanford Cancer Institute
Clinical Focus- Endocrinology
- Internal Medicine
Research InterestStudies of the role of the vitamin D receptor in the action of 1,25-dihydroxyvitamin D, the active vitamin D hormone. Current efforts are evaluating the vitamin D receptor in breast and prostate cancer, osteoporosis and rickets.
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Academic Appointments Professor, Medicine - Oncology
Member, Stanford Cancer Institute
Member, Bio-X
Professor, Pathology
Clinical Focus- Cancer > Lymphoma
- Hodgkin's Disease
- Hodgkin's Disease - Hematology
Research InterestMy laboratory investigates how oncogenes initiate and sustain tumorigenesis. I have developed model systems whereby I can conditionally activate oncogenes in normal human and mouse cells in tissue culture or in specific tissues of transgenic mice. In particular using the tetracycline regulatory system, I have generated a conditional model system for MYC-induced tumors. I have shown that cancers caused by the conditional over-expression of the MYC proto-oncogene regress with its inactivation.
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Academic Appointments Professor, Chemical and Systems Biology
Member, Stanford Cancer Institute
Professor, Biochemistry
Research InterestMy lab has two main goals: to understand mitotic regulation and to understand the systems-level logic of simple signaling circuits. We often make use of Xenopus laevis oocytes, eggs, and cell-free extracts for both sorts of study. We also carry out single-cell fluorescence imaging studies on mammalian cell lines. Our experimental work is complemented by computational and theoretical studies aimed at identifying the design principles of regulatory circuits.
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Academic Appointments Professor, Biology (School of Humanities and Sciences)
Member, Stanford Cancer Institute
Member, Bio-X
Research InterestThe long term goal of our research is to understand how proteins fold in living cells. My lab uses a multidisciplinary approach to address fundamental questions about molecular chaperones, protein folding and degradation. In addition to basic mechanistic principles, we aim to define how impairment of cellular folding and quality control are linked to disease, including cancer and neurodegenerative diseases and examine whether reengineering chaperone networks can provide therapeutic strategies.
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Academic Appointments Associate Professor, Biology (School of Humanities and Sciences)
Member, Stanford Cancer Institute
Research InterestWe study the molecular mechanisms by which chromatin-signaling networks effect nuclear and epigenetic programs, and how dysregulation of these pathways leads to disease. Our work centers on the biology of lysine methylation, a principal chromatin-regulatory mechanism that directs epigenetic processes. We study how lysine methylation events are generated, sensed, and transduced, and how these chemical marks integrate with other nuclear signaling systems to govern diverse cellular functions.
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Academic Appointments Professor, Medicine - Endocrinology, Gerontology, & Metabolism
Member, Stanford Cancer Institute
Member, Child Health Research Institute
Clinical Focus- Neuroendocrinology
- Endocrinology and Metabolism
Research InterestMechanism of genomic imprinting of insulin like growth factor-2 and other genes.Long range chromatin interactions Role of histone modifications and DNA methylation in gene expression.
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Academic Appointments Associate Professor, Obstetrics & Gynecology
Member, Stanford Cancer Institute
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Academic Appointments Member, Bio-X
Member, Stanford Cancer Institute
Research InterestCell cycle and cyclin control of DNA replication .
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Academic Appointments Professor, Dermatology
Member, Child Health Research Institute
Member, Stanford Cancer Institute
Member, Bio-X
Clinical Focus- Cancer > Cutaneous (Dermatologic) Oncology
- Dermatology
- General Dermatology
Research InterestWe work in epithelial tissue as a model system to study stem cell biology, cancer and new molecular therapeutics. Epithelia cover external and internal body surfaces and undergo constant self-renewal while responding to diverse environmental stimuli. Epithelial homeostasis precisely balances stem cell-sustained proliferation and differentiation-associated cell death, a balance which is lost in many human diseases, including cancer, 90% of which arise in epithelial tissues.
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Academic Appointments Professor, Biochemistry
Member, Bio-X
Member, Stanford Cancer Institute
Research Interest- Lung development and stem cells - Neural control of breathing - Lung diseases including lung cancer - New genetic model organisms for medicine
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Academic Appointments Professor, Medicine - Hematology
Member, Child Health Research Institute
Member, Stanford Cancer Institute
Member, Bio-X
Professor (By courtesy), Chemical and Systems Biology
Clinical Focus- Cancer > Hematology
- Medical Oncology
Research InterestWe explore angiogenesis, cancer genomics, intestinal stem cells, and hepatic glucose metabolism. Angiogenesis projects include endothelial miRNA and GPCR ko mice, blood-brain barrier regulation, stroke therapeutics and anti-angiogenic cancer therapy. Intestinal stem cell projects use primary intestinal culture and mouse genetics to study injury-inducible vs homeostatic stem cells. We use primary organoid cultures of diverse tissues for oncogene functional screening and therapeutics discovery.
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Academic Appointments Professor, Health Research & Policy - Biostatistics
Member, Stanford Cancer Institute
Professor (By courtesy), Natural Sciences Cluster - Statistics
Research InterestBiostatistics, clinical trials, longitudinal studies, casual inference from observational studies, genetic tissue banking, informed consent. Trial designs for dynamic (adaptive) treatment regimes, psychiatric research, cancer.
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Academic Appointments Professor, Pathology
Member, Stanford Cancer Institute
Member, Bio-X
Professor, Genetics
Professor (By courtesy), Biology (School of Humanities and Sciences)
Clinical Focus- Pathology
- Pathology and Laboratory Medicine
Research InterestFunction and evolution of the Myb oncogene family; function and evolution of E2F transcriptional regulators and RB tumor suppressors; epigenetic regulation of chromatin and chromosomes; cancer genetics.
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Academic Appointments Assistant Professor, Molecular & Cellular Physiology
Member, Stanford Cancer Institute
Research InterestWe study the primary cilium, a once-obscure cellular organelle recently "re-discovered" for its role in a number of signaling pathways. Defects in cilium biogenesis lead to a variety of hereditary disorders characterized by retinal degeneration, kidney cysts and obesity. Our goal is to characterize these disorders at the molecular and cellular levels to gain insight into the basic mechanisms of primary cilium biogenesis and to discover novel ciliary signaling pathways.
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Academic Appointments Professor, Biology (School of Humanities and Sciences)
Member, Stanford Cancer Institute
Member, Bio-X
Professor, Molecular & Cellular Physiology
Research InterestOur research objectives are to understand the cellular mechanisms involved in the development and maintenance of epithelial cell polarity. Polarized epithelial cells play fundamental roles in the ontogeny and function of a variety of tissues and organs.
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Academic Appointments Professor, Dermatology
Member, Bio-X
Member, Child Health Research Institute
Member, Stanford Cancer Institute
Clinical Focus- Cancer > Cutaneous (Dermatologic) Oncology
- Dermatology
- Skin Cancer
Research InterestHedgehog signaling has been implicated in the induction or maintenance of up to 25% of human tumors and a variety of birth defects. Our lab studies Sonic hedgehog (Shh) signaling in normal hair follicle development and in the pathogenesis of the most common human tumor, basal cell carcinoma (BCCs) of the skin. We are interested in how the local stromal environment regulates hedgehog signaling and hair follicle or tumor growth and invasion and developing novel targets for therapy.
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Academic Appointments Professor (Research), Urology
Member, Stanford Cancer Institute
Member, Bio-X
Research InterestMy research focuses on the molecular and cellular biology of the human prostate. Developing realistic experimental models is a major goal, and primary cultures of prostatic epithelial and stromal cells are my main model system. Our discoveries are relevant to prevention, detection, diagnosis and treatment of benign and malignant prostatic diseases.
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Academic Appointments Professor, Biochemistry
Member, Stanford Cancer Institute
Member, Bio-X
Research InterestThe goal of our research is to elucidate the molecular mechanisms by which proteins are targeted to specific membrane compartments. How do transport vesicles select their contents, bud, translocate through the cytoplasm, and then fuse with their targets? We study the Ras-like Rab GTPases--how they serve as master regulators of all receptor trafficking events. We also study how cells acquire cholesterol from the diet and from LDL.
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Academic Appointments Associate Professor, Pediatrics - Cancer Biology
Member, Child Health Research Institute
Member, Stanford Cancer Institute
Member, Bio-X
Associate Professor, Genetics
Research InterestWe are interested in the links between the basic cell cycle machinery and the factors controlling self-renewal, differentiation, and regeneration. In particular, we are intrigued by the differences and the similarities between "normal" cells, cancer cells, and stem cells. We investigate the mechanisms by which normal cells become tumor cells, and we aim to understand the differences between the proliferative response in response to injury and the hyperproliferative phenotype of cancer cells.
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Academic Appointments Professor, Genetics
Member, Bio-X
Member, Child Health Research Institute
Member, Stanford Cancer Institute
Research InterestWe are presently in an omics revolution in which genomes and other omes can be readily characterized. Our laboratory uses a variety of approaches to analyze genomes and regulatory networks. Our research focuses on yeast, an ideal model organism ideally suited to genetic analysis, and humans. 1) Transcriptomes To annotate genomes, we developed RNA sequencing for annotation the yeast and human transcriptomes. We discovered that the eukaryotic transcriptome is much more complex than previously..
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Academic Appointments Associate Professor, Biochemistry
Member, Bio-X
Member, Stanford Cancer Institute
Research InterestWe study the process of cell division. Our research is focused on understanding how chromosomes are segregated during mitosis and how cells divide during cytokinesis.
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Academic Appointments Associate Professor, Urology
Member, Stanford Cancer Institute
Member, Bio-X
Associate Professor, Genetics
Research InterestMy lab focuses on understanding the molecular mechanism of transcription factors that govern the transformation of normal mammalian cells to a neoplastic state. We are especially interested in the action of the nuclear hormone receptors and the interactions between the receptors and other signaling pathways in related human disorders.
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Academic Appointments Associate Professor (Research), Pediatrics - Cancer Biology
Member, Child Health Research Institute
Member, Bio-X
Member, Stanford Cancer Institute
Clinical Focus- Pediatric Hematology-Oncology
- Ewing's sarcoma
- Osteosarcoma
Research InterestOur laboratory is devoted to the analysis of pathways involved in the initiation, progression, and maintenance of cancer. Utilizing the mouse as a model system, we strive to understand aberrant oncogenic signaling, the role of the tumor microenvironment and the mechanisms involved in chemotherapy response and resistance at the molecular, cellular, and organismal levels.
Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital -
Academic Appointments Emeritus Faculty, Acad Council, Pathology
Member, Stanford Cancer Institute
Research InterestThe main focus of our research is to understand how cells maintain genome integrity by checkpoint mechanisms during chromosome replication.
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Academic Appointments Professor, Structural Biology
Member, Stanford Cancer Institute
Member, Bio-X
Professor, Molecular & Cellular Physiology
Professor, Stanford Synchrotron Radiation Lightsource - SSRL
Research InterestOur laboratory studies molecular interactions that underlie the establishment and maintenance of cell and tissue structure. Our specific areas of interest are the architecture and dynamics of intercellular adhesion junctions, the molecular basis of cell polarity, and the Wnt signaling pathway. We also have a long-standing interest in carbohydrate-based cellular recognition and adhesion.
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Academic Appointments Professor, Neurosurgery
Member, Stanford Cancer Institute
Research InterestOur goal is to define targets for cancer therapeutics by identifying alterations in signal transduction proteins. We first identified a naturally occurring mutant EGF receptor (EGFRvIII) and then delineated its unique signal transduction pathway. This work led to the identification of Gab1 followed by the discovery that JNK is constitutively active in tumors. We intiated using altered proteins as the target for vaccination, where an EGFRvIII based vaccine appears to be highly effective.
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Academic Appointments Associate Professor, Chemical and Systems Biology
Associate Professor, Developmental Biology
Member, Stanford Cancer Institute
Research InterestResearch in our lab focuses on mechanisms of epigenetic regulation in differentiation and development. In particular, we are studying the function of histone modifying enzymes in embryonic stem cell self-renewal and in early cell fate decisions. We are interested in the role of chromatin modifications in establishment and maintenance of gene expression patterns during normal and pathological development, and in nuclear reprogramming.
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