Department: Stanford Cancer Institute
Division: Molecular Profiling
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Academic Appointments Professor, Pathology
Member, Stanford Cancer Institute
Member, Bio-X
Professor, Microbiology & Immunology
Professor (By courtesy), Chemical and Systems Biology
Research InterestOur lab uses chemical, biochemical, and cell biological methods to study protease function in human disease. Projects include: 1) Design and synthesis of novel chemical probes for each of the primary protease families. 2) Understanding the role of proteolysis in the life cycle of the human parasites, Plasmodium falciparum and Toxoplasma gondii. 3) Defining the specific functional roles of proteases during the process of tumorogenesis. 4) In vivo imaging of protease activity
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Academic Appointments Professor, Urology
Member, Stanford Cancer Institute
Member, Bio-X
Clinical Focus- Cancer > Urologic Oncology
- Male Cancers - Prostate
- Prostate Cancer
Research InterestWe use genomic approaches to identify disease biomarkers. We are most interested in translating biomarkers into clinical practice in urological diseases with a particular focus in cancer.
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Academic Appointments Professor, Biochemistry
Member, Stanford Cancer Institute
Research InterestDr. Brown's research group uses diverse experimental and computational methods to investigate the logic and mechanisms that control a genome's expression program. The Brown laboratory is systematically characterizing the genetic scripts that control the expression of our genes, in normal development and physiology and in diseases like cancer, with a particular focus on post-transcriptional regulation. The Brown lab also develops strategies and assays for early detection and diagnosis of cancer.
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Academic Appointments Professor, Dermatology
Member, Stanford Cancer Institute
Member, Bio-X
Clinical Focus- Cancer > Cutaneous (Dermatologic) Oncology
- Dermatology
- General Dermatology
Research InterestOur research is focused on how the activities of hundreds or even thousands of genes (gene parties) are coordinated to achieve biological meaning. We have pioneered methods to predict, dissect, and control large-scale gene regulatory programs; these methods have provided insights into human development, cancer, and aging.
Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital -
Academic Appointments Professor, Medicine - Oncology
Member, Stanford Cancer Institute
Member, Bio-X
Professor, Biochemistry
Clinical Focus- Cancer > GI Oncology
- Oncology
Research InterestOur laboratory focuses on understanding how cells respond to DNA damage. Our research currently involves areas that interact with each other: repair of radiation damage, and transcriptional responses to DNA damage.
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Academic Appointments Professor - Med Center Line, Pediatrics - Hematology & Oncology
Member, Stanford Cancer Institute
Member, Child Health Research Institute
Clinical Focus- Pediatric Hematology-Oncology
- Ped Hematology/Oncology
Research InterestHematology/Oncology, Phase I drug studies for childhood cancer, overcoming multidrug resistance in leukemia and solid tumors, biology and treatment of acute nonlymphocytic leukemia, early detection of central nervous system leukemia by measuring growth, factor binding proteins.
Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital -
Academic Appointments Professor, Natural Sciences Cluster - Statistics
Professor, Health Research & Policy - Biostatistics
Member, Stanford Cancer Institute
Research InterestTheories of inference applied to biostatistical data;, the bootstrap method.
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Academic Appointments Associate Professor, Biochemistry
Member, Stanford Cancer Institute
Member, Bio-X
Research InterestOur lab engineers proteins and small-molecule drugs at atomic resolution through a combination of structural calculations and combinatorial library synthesis. Our goal is to elucidate predictive principles by which novel shapes and catalytic properties can be conferred accurately on designed polypeptides.
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Academic Appointments Professor, Natural Sciences Cluster - Statistics
Professor, Health Research & Policy - Biostatistics
Member, Stanford Cancer Institute
Member, Bio-X
Research InterestFlexible statistical modelling, datamining, bioinformatics, and statistical computing.
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Academic Appointments Professor, Biochemistry
Member, Bio-X
Member, Stanford Cancer Institute
Professor (By courtesy), Natural Sciences Cluster - Chemistry
Professor (By courtesy), Chemical Engineering
Research InterestOur research is aimed at understanding the chemical and physical behavior underlying biological macromolecules and systems, as these behaviors define the capabilities and limitations of biology. Toward this end we study folding and catalysis by RNA, as well as catalysis by protein enzymes.
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Academic Appointments Professor - Med Center Line, Surgery - General Surgery
Member, Bio-X
Member, Stanford Cancer Institute
Clinical Focus- Cancer > Breast Cancer
- General Surgery
Research InterestDr. Jeffrey was team leader of the multidisciplinary team from the School of Medicine, School of Engineering, and Genome Technology Center that invented the MagSweeper automated technology to isolate live circulating tumor cells (CTCs) from cancer patient blood for single cell analysis. Her lab characterizes CTCs in different cancers, investigating CTC profiles and mutations as potential companion diagnostics to define individual patient response to newer biologically-based cancer therapies.
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Academic Appointments Professor - Med Center Line, Pathology
Member, Stanford Cancer Institute
Clinical Focus- Anatomic/Clinical Pathology
- Pathology and Laboratory Medicine
Research InterestGynecological, breast and gastrointestinal pathology with major emphasis on ovarian cancer and ovarian tumors of low malignant potential. Pathology of familial and hereditary breast-ovarian-GI cancer.
Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital -
Academic Appointments Associate Professor, Medicine - Gastroenterology & Hepatology
Member, Stanford Cancer Institute
Associate Professor (By courtesy), Molecular & Cellular Physiology
Clinical Focus- Gastroenterology
Research InterestPancreatic and esophageal cancers are common and deadly cancers of the gastrointestinal tract. Our laboratory is currently focused on the characterization of genes important in tumor development and growth. Such genes will potentially serve as therapeutic targets. An additional focus of the laboratory is the development of diagnostic assays for the early detection of pancreatic and esophageal disease.
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Academic Appointments Assistant Professor - Med Center Line, Medicine - Hematology
Member, Stanford Cancer Institute
Clinical Focus- Cancer > Hematology
- Hematology
- Acute leukemia
Research InterestMy clinical activities combine the development of novel therapeutic modalities, translational research activities and epidemiological study of acute leukemia. My special focus is on the development of better, patient tailored therapies for young and elderly patients with acute leukemia.
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Academic Appointments Assistant Professor - Med Center Line, Medicine - Oncology
Member, Stanford Cancer Institute
Clinical Focus- Cancer > Thoracic Oncology
- Thoracic Oncology
- Lung Cancer
Research InterestApplying new technologies to the diagnosis, characterization, and treatment of non-small cell lung cancer.
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Academic Appointments Associate Professor, Pathology
Member, Bio-X
Member, Stanford Cancer Institute
Research InterestOur laboratory uses genomic approaches to explore patterns of gene expression and gene copy number alteration in human cancer cell line model systems and in tumors, with the goals of better understanding cancer, and developing novel diagnostic and therapeutic strategies.
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Academic Appointments Professor, Medicine - Infectious Diseases
Member, Bio-X
Member, Stanford Cancer Institute
Professor, Microbiology & Immunology
Clinical Focus- Infectious Disease
Research InterestMy investigative program focuses on human-microbe interactions and human microbial ecology, and primarily concerns the ecology of human indigenous microbial communities; a secondary interest concerns the classification of humans with systemic infectious diseases, based on features of genome-wide gene transcript abundance patterns and pther aspects of the host response.
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Academic Appointments Professor - Med Center Line, Medicine - Cardiovascular Medicine
Member, Stanford Cancer Institute
Clinical Focus- Lymphatic Diseases
- Cardiology (Heart)
- Cardiology (Heart), Preventive
Research InterestMy clinical research includes studies on risk factor modification in atherosclerosis and coronary artery disease; clinical trials involving medical therapies for peripheral arterial insufficiency; coronary angiogenesis; therapy of lymphedema; atherand photodynamic therapy in atherosclerosis.
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Academic Appointments Associate Professor, Genetics
Member, Stanford Cancer Institute
Research InterestEvolution and the adaptive landscape using yeast as a model; Defining yeast transcriptomes; chromosomal evolution in hybrid yeast species
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Academic Appointments Professor, Biochemistry
Member, Stanford Cancer Institute
Member, Bio-X
Research InterestThe general research interest of this laboratory is the molecular basis of cell motility. We have three specific research interests, the molecular basis of energy transduction that leads to ATP-driven myosin movement on actin, the biochemical basis of the regulation of actin and myosin interaction and their assembly states, and the roles these proteins play in vivo, in cell movement and changes in cell shape.
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Academic Appointments Professor, Health Research & Policy - Biostatistics
Member, Stanford Cancer Institute
Member, Bio-X
Professor, Natural Sciences Cluster - Statistics
Research InterestMy research is in applied statistics and biostatistics. I specialize in computer-intensive methods for regression and classification, bootstrap, cross-validation and statistical inference, and signal and image analysis for medical diagnosis.
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