Department: Stanford Cancer Institute
Division: Cancer Immunology
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Academic Appointments Emeritus Faculty, Acad Council, Health Research & Policy - Biostatistics
Member, Stanford Cancer Institute
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Academic Appointments Professor, Pathology
Member, Stanford Cancer Institute
Member, Bio-X
Clinical Focus- Pathology Anatomic
- Pathology and Laboratory Medicine
Research InterestOur interests include: 1) The physiology and significance of lymphocyte homing in local and systemic immunity; 2) biochemical and genetic studies of molecules that direct leukocyte recruitment; 3) cellular and molecular genetic studies of leukocyte chemotaxis and the role of chemokines; 4) vascular differentiation in normal and pathologic inflammatory states; 5) systems and chemical biology approaches to understanding the regulation of lymphocyte trafficking programs.
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Academic Appointments Assistant Professor, Pediatrics - Immunology and Allergy
Member, Child Health Research Institute
Member, Bio-X
Member, Stanford Cancer Institute
Clinical Focus- Allergy and Immunology
- Pediatric Allergy/Immun
Research InterestOur laboratory's goal is to address fundamental and therapeutic questions in immunology using innovative nanotechnological and biophysical approaches to visualize and manipulate cells. Our primary focus is on understanding the molecular controls that balance T cell activation versus tolerance. The ultimate aim of our work is to manipulate T cell signaling pathways to control immunologically-mediated diseases.
Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital -
Academic Appointments Professor, Microbiology & Immunology
Member, Stanford Cancer Institute
Research InterestContribution of T cells to immunocompetence and autoimmunity; how the immune system clears infection, avoids autoimmunity and how infection impacts on the development of immune responses.
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Academic Appointments Professor, Microbiology & Immunology
Member, Bio-X
Member, Stanford Cancer Institute
Research InterestMolecular mechanisms of lymphocyte recognition and differentiation; molecular genetics and expression of T-cell receptor genes. Dynamics and functionality of specific T cell populations in human cancer.
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Academic Appointments Professor, Pathology
Member, Stanford Cancer Institute
Professor, Medicine - Immunology & Rheumatology
Clinical Focus- Pathology
- Pathology and Laboratory Medicine
Research InterestDendritic cells, NK cells and T cells; functional proteins and genes; immunotherapeutic approaches to cancer and autoimmune disease.
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Academic Appointments Professor, Medicine - Immunology & Rheumatology
Member, Stanford Cancer Institute
Clinical Focus- Immunology
- Immunology and Rheumatology
Research InterestMy lab of molecular and cellular immunology is interested in research in the general field of T cell activation and autoimmunity. We use lentiviral mediated transduction of murine dendritic cells with immunoregulatory proteins for site specific and targeted immunotherapy. We have identified and characterized a gene (GRAIL) that seems to control T cell anergy. We have recently characterized a gene (Deaf1) that seems to play a major role in peripheral tolerance in T1D.
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Academic Appointments Professor, Pathology
Member, Stanford Cancer Institute
Member, Bio-X
Professor, Microbiology & Immunology
Clinical Focus- Pathology
- Pathology and Laboratory Medicine
Research InterestThe goals of Dr. Galli's laboratory are to understand the regulation of mast cell and basophil development and the expression of mast cell and basophil function, and to develop and use genetic approaches to elucidate the roles of these cells in health and disease.
Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital -
Academic Appointments Professor, Molecular & Cellular Physiology
Member, Bio-X
Member, Stanford Cancer Institute
Professor, Structural Biology
Research InterestStructural and functional studies of transmembrane receptor interactions with their ligands in systems relevant to human health and disease - primarily in immunity, infection, and neurobiology. We study these problems using protein engineering, structural, biochemical, and combinatorial biology approaches.
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Academic Appointments Professor (Research), Genetics
Member, Stanford Cancer Institute
Research InterestB-cell development; Ig rearrangement and repertoire analysis; T cell regulation of antibody responses; T cell subsets; glutathione regulation of HIV disease progression; Fluorescence-Activated Cell Sorting (FACS) related software development and gene arrays.
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Academic Appointments Assistant Professor, Medicine - Oncology
Member, Stanford Cancer Institute
Clinical Focus- Cancer > GI Oncology
- Medical Oncology
- Oncology (Cancer)
Research InterestCancer genomics and genetics, translational applications of next generation sequencing technologies, development of molecular signatures as prognostic and predictive biomarkers in oncology, primary genomic and proteomic technology development
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Academic Appointments Emeritus Faculty, Acad Council, Pediatrics
Member, Stanford Cancer Institute
Member, Bio-X
Research InterestMechanisms and therapies for infection, cancer, autoimmunity and transplantation.
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Academic Appointments Member, Stanford Cancer Institute
Clinical Focus- Hematology
- Leukemia - Hematology
Research InterestUnderstanding the biology of cancer-T cell interactions.
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Academic Appointments Professor - Med Center Line, Pediatrics - Immunology and Allergy
Member, Child Health Research Institute
Member, Stanford Cancer Institute
Clinical Focus- Pediatric Infectious Disease
- Primary Immunodeficiency
Research InterestMy laboratory has two major research interests. First, to define cellular and molecular mechanisms that limit T cell responses to vaccines and pathogens during normal early postnatal development and in cases of inherited genetic immunodeficiencies. Second, to determine how these limitations in immunity can be overcome by using novel approaches for vaccine adjuvants, with a particular focus on anti-viral vaccines.
Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital -
Academic Appointments Professor (Research), Surgery - Multi-Organ Transplantation
Member, Bio-X
Member, Child Health Research Institute
Member, Stanford Cancer Institute
Research InterestEBV B cell lymphomas; pathways of immune evasion in the growth and survival of EBV B cell lymphomas; mechanisms of graft rejection and tolerance induction; stem cell and solid organ transplantation.
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Academic Appointments Emeritus Faculty, Acad Council, Medicine - Immunology & Rheumatology
Member, Stanford Cancer Institute
Clinical Focus- Immunology
- Immunology and Rheumatology
Research InterestThe lab is studying the mechanisms controlling B cell responsiveness and the balance between tolerance and autoimmunity. B cells deficient in CD72 are hyperresponsive to stimulation through the B cell receptor. We are examining the alterations in B cell signaling in these B cells and the mechanisms by which CD72 deficiency partially abrogates anergic tolerance. We hope to learn how deficiency in CD72 leads to spontaneous autoimmunity and increased susceptibility to induced autoimmune disease.
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Academic Appointments Professor, Microbiology & Immunology
Member, Bio-X
Member, Stanford Cancer Institute
Research InterestOur laboratory studies virus-host interactions with an emphasis microRNA-mediated gene regulation and on translational control. The mechanism by which a liver-specific microRNA regulates hepatitis C virus genome replication is under intense scrutiny. In addition, the mechanism of internal ribosome entry in certain cellular and viral mRNAs and its biological role in growth and development is being investigated.
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