- Trial of Zolpidem, Eszopiclone, and Other GABA Agonists in a Patient with Progressive Supranuclear Palsy Case Reports in Medicine 2014; 2014: 5
- Evaluating The Cost-Effectiveness Of Catheter Ablation Of Atrial Fibrillation Arrhythmia & Electrophysiology Review 2014; 3 (3)
- Spatial organization of dendritic cells within tumor draining lymph nodes impacts clinical outcome in breast cancer patients JOURNAL OF TRANSLATIONAL MEDICINE 2013; 11
Center-surround vs. distance-independent lateral connectivity in the olfactory bulb
FRONTIERS IN NEURAL CIRCUITS
Lateral neuronal interactions are known to play important roles in sensory information processing. A center-on surround-off local circuit arrangement has been shown to play a role in mediating contrast enhancement in the visual, auditory, and somatosensory systems. The lateral connectivity and the influence of those connections have been less clear for the olfactory system. A critical question is whether the synaptic connections between the primary projection neurons, mitral and tufted (M/T) cells, and their main inhibitory interneurons, the granule cells (GCs), can support a center-surround motif. Here, we study this question by injecting a "center" in the glomerular layer of the olfactory bulb (OB) with a marker of synaptic connectivity, the pseudorabies virus (PRV), then examines the distribution of labeling in the "surround" of GCs. We use a novel method to score the degree to which the data fits a center-surround model vs. distance-independent connectivity. Data from 22 injections show that M/T cells generally form lateral connections with GCs in patterns that lie between the two extremes.
View details for DOI 10.3389/fncir.2012.00034
View details for Web of Science ID 000304625700001
View details for PubMedID 22666190
Learning to live together: harnessing regulatory T cells to induce organ transplant tolerance.
Yale journal of biology and medicine
2011; 84 (4): 345-351
The discovery of immune cells with regulatory effects has created considerable excitement for their potential use in inducing tolerance to transplanted tissues. Despite the fact that these cells possess essential functions in vivo, attempts to translate them into effective clinical therapies has proved challenging due to a number of unanticipated complexities in their behavior. This article provides a broad summary of research done to understand the largest of the regulatory cell subtypes, namely CD4+Foxp3+ Regulatory T cells (T(Regs)). Special attention will be paid to current and future difficulties in using T(Regs) clinically, as well as room for improvement and innovation in this field.
View details for PubMedID 22180672
Lateral connectivity in the olfactory bulb is sparse and segregated
FRONTIERS IN NEURAL CIRCUITS
Lateral connections in the olfactory bulb were previously thought to be organized for center-surround inhibition. However, recent anatomical and physiological studies showed sparse and distributed interactions of inhibitory granule cells (GCs) which tended to be organized in columnar clusters. Little is known about how these distributed clusters are interconnected. In this study, we use transsynaptic tracing viruses bearing green or red fluorescent proteins to further elucidate mitral- and tufted-to-GC connectivity. Separate sites in the glomerular layer were injected with each virus. Columns with labeling from both viruses after transsynaptic spread show sparse red or green GCs which tended to be segregated. However, there was a higher incidence of co-labeled cells than chance would predict. Similar segregation of labeling is observed from dual injections into olfactory cortex. Collectively, these results suggest that neighboring mitral and tufted cells receive inhibitory inputs from segregated subsets of GCs, enabling inhibition of a center by specific and discontinuous lateral elements.
View details for DOI 10.3389/fncir.2011.00005
View details for Web of Science ID 000290153700001
View details for PubMedID 21559072
- Hydrophilic Graft Modification of a Commercial Crystalline Polyolefin J. Polym. Sci. Part A: Polym. Chem. 2008; 46: 3533-3545
- Regioselective functionalization of high-molecular-weight crystalline polyolefins via C-H activation of methyl side group Polymer Preprints 2006; 47: 247-248