Bio

Honors & Awards


  • NIH National Research Service Award (NRSA) Parent F31-Diversity, NIH (April 2012)
  • Diversifying Academia, Recruiting Excellence Doctoral Stanford Fellowship, Vice Provost of Graduate Education (Aug. 2011 - Aug. 2013)
  • National Science Foundation (NSF) Graduate Fellowship, NSF (Sept. 2008 - Aug. 2011)

Professional Education


  • Master of Science, Stanford University, MED-MS (2014)
  • Doctor of Philosophy, Stanford University, GENE-PHD (2014)
  • Bachelor of Science, New Mexico State Univ, Las Cruces, Biochemistry (2006)

Stanford Advisors


  • Lei Qi, Postdoctoral Faculty Sponsor

Research & Scholarship

Lab Affiliations


Publications

Journal Articles


  • Human germ cell formation in xenotransplants of induced pluripotent stem cells carrying X chromosome aneuploidies. Scientific reports Dominguez, A. A., Chiang, H. R., Sukhwani, M., Orwig, K. E., Reijo Pera, R. A. 2014; 4: 6432-?

    Abstract

    Turner syndrome is caused by complete or partial loss of the second sex chromosome and is characterized by spontaneous fetal loss in >90% of conceptions. Survivors possess an array of somatic and germline clinical characteristics. Induced pluripotent stem cells (iPSCs) offer an opportunity for insight into genetic requirements of the X chromosome linked to Turner syndrome. We derived iPSCs from Turner syndrome and control individuals and examined germ cell development as a function of X chromosome composition. We demonstrate that two X chromosomes are not necessary for reprogramming or maintenance of pluripotency and that there are minimal differences in gene expression, at the single cell level, linked to X chromosome aneuploidies. Formation of germ cells, as assessed in vivo through a murine xenotransplantation model, indicated that undifferentiated iPSCs, independent of X chromosome composition, are capable of forming germ-cell-like cells (GCLCs) in vivo. In combination with clinical data regarding infertility in women with X chromosome aneuploidies, results suggest that two intact X chromosomes are not required for human germ cell formation, qualitatively or quantitatively, but rather are likely to be required for maintenance of human germ cells to adulthood.

    View details for DOI 10.1038/srep06432

    View details for PubMedID 25242416

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