School of Medicine
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Manish J. Butte, MD PhD
Assistant Professor of Pediatrics (Immunology) and, by courtesy, of Materials Science and Engineering
Current Research and Scholarly Interests Our laboratory's goal is to address fundamental and therapeutic questions in immunology using innovative nanotechnological and biophysical approaches to visualize and manipulate cells. Our primary focus is on understanding the molecular controls that balance T cell activation versus tolerance. The ultimate aim of our work is to manipulate T cell signaling pathways to control immunologically-mediated diseases.
Professor (Research) of Pediatrics, Emerita
Current Research and Scholarly Interests Our group uses molecular biology, biochemistry, and cellular immunology to investigate the activation and effector function of T lymphocytes. Research in the laboratory is currently focused on three areas: granulysin, a lytic molecule expressed late (7-12 days) after T cell activation; identification of correlates of immunity in diseases such as tuberculosis; and tolerance. The long term goal of this work is to develop new ways to treat human disease.
Wen-Yuan Elena Hsieh
Instructor, Pediatrics - Immunology and Allergy
Current Research and Scholarly Interests I have an interest in developing and applying high dimensional proteomic analysis to pediatric systemic inflammatory disease and immunodeficiency disorders, with the goal of translating this directly to patient care by identifying targets for therapy and new risk stratifications based on functional read-outs. Specifically, I am interested in understanding innate immune signaling and cytokine networks in systemic lupus erythematosus (SLE) and primary immunodeficiency with inflammatory complications, as well as normal innate immune development and the relationship between the two. I am currently working with Dr. Garry Nolan, in whose laboratory mass cytometry was initially developed and applied to the understanding of normal immunophenotype and signaling in peripheral blood samples. I am developing expertise in single-cell mass cytometry analysis of human peripheral blood samples and the different data analysis methods of high dimensional datasets. I continue to enjoy an active role in caring for children with inflammatory and immunodeficient disorders.
David B. Lewis M.D.
Professor of Pediatrics (Immunology) at the Lucile Salter Packard Children's Hospital
Current Research and Scholarly Interests My laboratory has two major research interests. First, to define cellular and molecular mechanisms that limit T cell responses to vaccines and pathogens during normal early postnatal development and in cases of inherited genetic immunodeficiencies. Second, to determine how these limitations in immunity can be overcome by using novel approaches for vaccine adjuvants, with a particular focus on anti-viral vaccines.
Clinical Associate Professor, Pediatrics - Immunology and Allergy
Current Research and Scholarly Interests Bioinformatics
Kari Nadeau, MD, PhD
Professor of Medicine (Pulmonary and Critical Care Medicine), of Pediatrics (Allergy and Clinical Immunology) and, by courtesy, of Otolaryngology - Head and Neck Surgery at the Lucile Salter Packard Children's Hospital
Current Research and Scholarly Interests Kari Nadeau, MD, PhD, Allergy, Immunology and Asthma
Our research interests in the laboratory focus on the role of human T cells, specifically natural regulatory T cells (Treg, in immunological diseases. We aim to differentiate the mechanisms of action of regulatory T cell suppressive function. We study how pollution, such as diesel exhause, disrupt Treg suppressive function and how chemokines, like lymphotactin, enhance Treg suppressive function. We also study Treg function in tolerance.