School of Medicine
Showing 1-10 of 49 Results
Russ B. Altman
Kenneth Fong Professor and Professor of Bioengineering, of Genetics, of Medicine (General Medical Discipline) and, by courtesy, of Computer Science
Current Research and Scholarly Interests I refer you to my web page for detailed list of interests, projects and publications. In addition to pressing the link here, you can search "Russ Altman" on http://www.google.com/
Professor of Radiation Oncology (Radiation Biology) and of Genetics
Current Research and Scholarly Interests Our research is aimed at defining the pathways of p53-mediated apoptosis and tumor suppression, using a combination of biochemical, cell biological, and mouse genetic approaches. Our strategy is to start by generating hypotheses about p53 mechanisms of action using primary mouse embryo fibroblasts (MEFs), and then to test them using gene targeting technology in the mouse.
Associate Professor of Genetics
Current Research and Scholarly Interests Our laboratory is focused on identifying proteins based upon their ability to alter a variety of cell fate decisions - including mesodermal, endodermal, neural, endothelial, and somitic - within the vertebrate embryo.
Assistant Professor of Genetics and of Developmental Biology
Current Research and Scholarly Interests Our lab studies how intricate control of gene expression and cell signaling is regulated on a minute-by-minute basis to give rise to the remarkable diversity of cell types and tissue morphology that form the living blueprints of developing organisms. This research aims to add a new dimension to our understanding of how cells “know” where to go, when to move and differentiate by employing novel technologies that probe these questions at a highly molecular and nanoscale level. Work in the Barna lab is presently split into two main research efforts. The first is investigating “specialized ribosomes” and mRNA translation in control of gene expression genome-wide in space and time during development. This research is opening a new field of study in which fundamental aspects of gene regulation are controlled by ribosomes harboring a unique activity that “select” for specific mRNAs to translate by virtue of unique RNA regulons embedded within 5’UTRs. The second research effort is centered on employing state-of-the-art live cell imaging to visualize cell signaling and cellular control of organogenesis. This research has led to the realization of a novel means of cell-cell communication dependent on a dense network of actin-based cellular extension within developing organs that interconnect and facilitate the precise transmission of molecular information between cells.
Professor of Genetics and of Pediatrics, Emeritus
Current Research and Scholarly Interests Genetics of color variation
Assistant Professor of Genetics
Current Research and Scholarly Interests We are interested in the mechanism by which bacterial toxins, viruses, and protein aggregates hijack the secretory pathway and kill cells. More broadly, we investigate how diverse stresses (biological, chemical) signal to the apoptotic machinery.
To pursue these interests, we develop widely applicable new technologies to screen and measure genetic interactions; these include high-complexity shRNA libraries, which have allowed the first systematic genetic interaction maps in mammalian cells.
Assistant Professor of Medicine (Hematology) and of Genetics
Current Research and Scholarly Interests The Bhatt lab is exploring how the microbiota is intertwined with states of health and disease. We apply the most modern genetic tools in an effort to deconvolute the mechanism of human diseases.
Consulting Professor, Genetics
Current Research and Scholarly Interests The lesions of Parkinson's disease (PD) spread within the central nervous system (CNS) with characteristics of prion diseases. The prion in this case is a misfolded form of alpha-synuclein. We are investigating the mechanism of spread on alpha-synuclein prions with a special attention to axonal transport and transfer of prions between neurons. Understanding these pathways could lead to using drugs to slow down or halt disease progression.
Michele and Timothy Barakett Endowed Professor
Current Research and Scholarly Interests Our lab studies the molecular basis of longevity. We are interested in the mechanism of action of known longevity genes, including FOXO and SIRT, in the mammalian nervous system. We are particularly interested in the role of these longevity genes in neural stem cells. We are also discovering novel genes and processes involved in aging using two short-lived model systems, the invertebrate C. elegans and an extremely short-lived vertebrate, the African killifish N. furzeri.
Professor of Biomedical Data Science, of Genetics and, by courtesy, of Biology
Current Research and Scholarly Interests My research focuses on analyzing genome wide patterns of variation within and between species to address fundamental questions in biology, anthropology, and medicine. My group works on a variety of organisms and model systems ranging from humans and other primates to domesticated plant and animals. Much of our research is at the interface of computational biology, mathematical genetics, and evolutionary genomics.