School of Medicine
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Stephen A. Baccus
Associate Professor of Neurobiology
Current Research and Scholarly Interests We study how the neural circuitry of the vertebrate retina encodes visual information and performs computations. To control and measure the retinal circuit, we present visual images while performing simultaneous two-photon imaging and multielectrode recording. We perturb the circuit as it operates using simultaneous intracellular current injection and multielectrode recording, and use the resulting large data sets to construct models of retinal computation.
Professor of Neurobiology, of Developmental Biology, of Neurology and, by courtesy, of Ophthalmology
Current Research and Scholarly Interests Our lab is interested in the neuronal-glial interactions that underlie the development and function of the mammlian central nervous system.
Shooter Family Professor
Current Research and Scholarly Interests The Clandinin lab focuses on understanding how neuronal circuits assemble and function to perform specific computations and guide behavior. Taking advantage of a rich armamentarium of genetic tools available in the fruit fly, combined with imaging, physiology and analytical techniques drawn from systems neuroscience, we examine a variety of visual circuits.
Assistant Professor of Applied Physics and, by courtesy, of Neurobiology and of Electrical Engineering
Current Research and Scholarly Interests Theoretical / computational neuroscience
Assistant Professor of Neurobiology
Current Research and Scholarly Interests My laboratory studies the cellular and molecular mechanisms underlying the organization of cortical circuits important for spatial navigation and memory. We are particularly focused on medial entorhinal cortex, where many neurons fire in spatially specific patterns and thus offer a measurable output for molecular manipulations. We combine electrophysiology, genetic approaches and behavioral paradigms to unravel the mechanisms and behavioral relevance of non-sensory cortical organization. Our first line of research is focused on determining the cellular and molecular components crucial to the neural representation of external space by functionally defined cell types in entorhinal cortex (grid, border and head direction cells). We plan to use specific targeting of ion channels, combined with in vivo tetrode recordings, to determine how channel dynamics influence the neural representation of space in the behaving animal. A second, parallel line of research, utilizes a combination of in vivo and in vitro methods to further parse out ionic expression patterns in entorhinal cortices and determine how gradients in ion channels develop. Ultimately, our work aims to understand the ontogenesis and relevance of medial entorhinal cortical topography in spatial memory and navigation.
Andrew D. Huberman, Ph.D.
Associate Professor of Neurobiology
Current Research and Scholarly Interests My lab is focused on brain function, development and repair with emphasis on regeneration to prevent and cure blindness.
We also study the neural circuits that control visual fear and are developing tools to re-map them and treat anxiety disorders.
The specific conditions we aim to understand and develop therapeutic strategies for include: retinal and optic nerve damage in glaucoma, and disorders of sensory-limbic function, such as depression and PTSD.
Adjunct Professor, Neurobiology
Current Research and Scholarly Interests Bioethics
Stem Cell Ethics
Eric I. Knudsen
Edward C. and Amy H. Sewall Professor in the School of Medicine, Emeritus
Current Research and Scholarly Interests Cellular mechanisms of spatial attention and learning, studied in the central nervous system in birds, using behavioral, systems, cellular and molecular techniques.
Assistant Professor of Neurobiology, of Bioengineering and, by courtesy, of Chemical and Systems Biology
Current Research and Scholarly Interests Our lab applies biochemical and engineering principles to the development of protein-based tools for molecular imaging and gene therapy. Topics of investigation include fluorescent proteins structure and biophysics, fluorescent protein-based biosensors, spatiotemporal analysis of protein translation pathways, chemical control of protein translation, and light-responsive proteins.