School of Medicine
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Associate Professor of Medicine (Endocrinology, Gerontology and Metabolism)
Current Research and Scholarly Interests Our lab is interested in understanding molecular processes that underlie aging and age-associated pathologies in mammals. We focus on a family of genes, the SIRTs, which regulate stress resistance and lifespan in lower organisms such as yeast, worms, and flies. In mammals, we recently uncovered a number of ways in which SIRT factors may contribute to cellular and organismal aging by regulating resistance to various forms of stress. We have now begun to characterize the molecular mechanisms by which these SIRT factors function. In particular, we are interested in how SIRT factors regulate chromatin, the molecular structure in which the DNA of mammalian genomes is packaged, and how such functions may link genome maintenance to stress resistance and aging.
Professor of Medicine (Endocrinology, Gerontology and Metabolism) at the Santa Clara Valley Medical Center, Emeritus
Current Research and Scholarly Interests Investigation of the epidemiology of diabetic ketoacidosis (DKA) at a public hospital. All cases of DKA at SCVMC occurring over the past 5 years have been identified. Of the 480 cases of DKA, about 1/3 are in Type II diabetics, and 2/3 in Type I diabetics. We are exploring the causes of DKA in the two groups.