School of Medicine
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Anna H. Messner, M.D.
Professor of Otolaryngology-Head and Neck Surgery and of Pediatrics at the Stanford University Medical Center and the Lucile Salter Packard Children's Hospital
Current Research and Scholarly Interests -- Obstructive sleep apnea in children
-- Postoperative tonsillectomy care
-- Medical Education
Sam P. Most, M.D., F.A.C.S.
Professor of Otolaryngology - Head and Neck Surgery at the Stanford University Medical Center
Current Research and Scholarly Interests 1. Evidence-based medicine in Facial Plastic Surgery
The primary goal of this research program is to develop a higher standard of care for facial plastic surgery patients. One example of this is the evelopment of prospective studies that examine the efficacy of new or existing surgical techniques in facial plastic surgery. One clinical problem we have already begun to examine is nasal obstruction.
2. Examination of facial nerve injury and biological correlates of functional recovery.
Assistant Professor of Otolaryngology - Head and Neck Surgery
Current Research and Scholarly Interests Hearing is one of the most sensitive functions controlled by thyroid hormone (TH). TH is required for the timely coordination of a complex set of differentiation events in the maturing cochlea. Hypothyroidism retards the differentiation of the cochlea, including synaptogenesis, neurogenesis and myelinogenesis. The mechanisms that prompt the progression of these developmental events are poorly understood. Our preliminary data shows that many genes are differentially regulated by thyroid hormone in the cochlea.
Identifying which of these genes play important roles in cochlear hair cell innervation and synapse formation will further basic understanding about how the auditory system develops. In addition, knowledge of these genes could help devise strategies for stimulating the innervation of newly generated hair cells. To establish or restore hearing, it is vital that newly formed hair cells be connected functionally to the brain. We expect that our research will contribute to this important clinical/translational research effort by identifying genes involved in stimulating innervation and synapse formation.