School of Medicine
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Professor of Chemistry and, by courtesy, of Structural Biology
Current Research and Scholarly Interests The central theme of our research is to develop and apply novel theoretical methods to understand the physical properties of biological molecules, such as proteins, nucleic acids, lipid membranes, and small molecule therapeutics (eg protein folding or lipid vesicle fusion). As these phenomena are complex, my research employs novel theoretical and computational techniques. We apply these methods to develop novel therapeutics for protein misfolding diseases, such as Alzheimer's Disease.
Professor of Structural Biology and of Microbiology and Immunology
Current Research and Scholarly Interests The Parham laboratory investigates the biology, genetics, and evolution of MHC class I molecules and NK cell receptors.
Elisabetta Viani Puglisi
Assistant Professor (Research) of Structural Biology
Current Research and Scholarly Interests Viral infections and subsequent host response depend on multiple RNA-protein interaction. My research focuses on the structural and functional characterization of RNA-protein complexes involved in viral infection. Current research aims to understand how the Human Immunodeficiency Virus (HIV) initiates its replication upon host infection. We use NMR spectroscopy and x-ray crystallography to study the structure of the initiation complex, formed by a host tRNA and HIV genomic RNA, coupled with biochemical and biophysical methods to understand functional properties. The goal of this research is to gain a molecular view of HIV replication initiation, and use this information to develop new therapeutic approaches to combat HIV.
Joseph (Jody) Puglisi
Professor of Structural Biology
Current Research and Scholarly Interests The Puglisi group investigates the role of RNA in cellular processes and disease. We investigate dynamics using single-molecule approaches. Our goal is a unified picture of structure, dynamics and function. We are currently focused on the mechanism and regulation of translation, and the role of RNA in viral infections. A long-term goal is to target processes involving RNA with novel therapeutic strategies.