School of Medicine

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  • Maria Grazia Roncarolo

    Maria Grazia Roncarolo

    Professor of Pediatrics (Stem Cell Transplantation) and of Medicine (Blood and Marrow Transplantation)

    Current Research and Scholarly Interests Research Interests
    Immunetolerance: Mechanisms underlying T-cell tolerance, induction of T-cell anergy and regulatory T cells; Immunomodulation: mAbs, proteins and low molecular weight compounds which can modulate T-cell activation; Primary immunodeficiencies: Characterization of molecular and immunological defects; Gene therapy: Gene transduction of hematopoietic cells for gene therapy in primary immunodeficiencies and metabolic diseases; Hematopoiesis: Mechanisms underlying growth and differentiation of hematopoietic stem cells; Transplantation: Immune reconstitution and T-cell tolerance after allogenic stem cell transplantation; Cytokines/Cytokine receptors: Role in regulation of immune and inflammatory responses

    Clinical Interests
    Primary Immunodeficiencies
    Monogenic Autoimmune Disorders
    Allogenic Bone Marrow Transplantation
    Gene Therapy Clinical Trials
    Cell Therapy Clinical Trials
    Clinical Trials in Autoimmune Diseases and Organ Transplantation
    Clinical Trials in Hemoglobinopathies

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