School of Medicine
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Assistant Professor of Bioengineering and, by courtesy, of Developmental Biology
Bio We are a discovery-driven research group working at the interface between statistical physics, developmental biology, and bioengineering. We combine quantitative organism-wide fluorescence imaging ("deep imaging"), functional genomics ("deep sequencing"), and statistical modeling to study systems biology and evolutionary cell biology of flatworms, including free living planarians and parasitic flukes. Using these animals, we seek to understand quantitatively the fundamental rules that control stem cell collective behavior to optimize tissue regeneration, remolding, and adaptation.
Virginia & D.K. Ludwig Professor for Clinical Investigation in Cancer Research, Professor of Developmental Biology and, by courtesy, of Biology
Current Research and Scholarly Interests Stem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis.
Professor of Chemical and Systems Biology and of Developmental Biology
Current Research and Scholarly Interests Interactions between the genome and its cellular and signaling environments, which ultimately occur at the level of chromatin, are the key to comprehending how cell-type-specific gene expression patterns arise and are maintained during development. Research in our laboratory is focused on understanding how information encoded by the genome is integrated with the transcriptional machinery and epigenetic regulation to allow for emergence of form and function during embryogenesis.