Bio

Clinical Focus


  • Neonatology

Academic Appointments


Administrative Appointments


  • Associate Director, ANES 306N Critical Care Core Clerkship - Neonatal (2015 - Present)

Honors & Awards


  • T32 Training Grant Trainee, National Institutes of Health (7/1/2011-6/30/2012)
  • Harry Machen Lyon Fellow, Child Health Research Institute and Stanford CTSA (7/1/2012-6/30/2013)

Boards, Advisory Committees, Professional Organizations


  • Instructor, Neonatal Resuscitation Program (2010 - Present)
  • Fellow, American Academy of Pediatrics (2015 - Present)
  • Member, American Academy of Pediatrics (2007 - 2013)
  • Member, El Camino Hospital Neonatal Code Subcommittee (2015 - Present)

Professional Education


  • Board Certification, Neonatal-Perinatal Medicine, American Board of Pediatrics (2016)
  • Board Certification: Pediatrics, American Board of Pediatrics (2012)
  • Fellowship:Stanford University (2013) CA
  • Residency:University of Minnesota (2010) MN
  • Internship:University of Minnesota (2008) MN
  • Medical Education:KECK School of Medicine of USC - Graduate Medical Education (2007) CA

Research & Scholarship

Clinical Trials


  • Predictors of Pulmonary Hypertension Risk in Premature Infants With Bronchopulmonary Dysplasia Not Recruiting

    A lung condition called bronchopulmonary dysplasia (BPD) is a major cause of poor outcomes and death for premature infants. Infants with BPD are also at high risk for pulmonary hypertension (PH)—an important contributor to their condition. Previous research has suggested that a protein in the blood, endothelin-1 (ET-1), is associated with pulmonary disease. This study aims to investigate the incidence of PH and levels of ET-1 among premature babies with BPD. It will also potentially allow us to focus further research efforts and treatment towards these infants, some of our sickest patients at LPCH.

    Stanford is currently not accepting patients for this trial. For more information, please contact Christine Johnson, MD, 650 723-5711.

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  • Remodulin as Add-on Therapy for the Treatment of Persistent Pulmonary Hypertension of the Newborn Recruiting

    This pilot study aims to assess the safety and treatment effect of acute dosing with IV Remodulin in neonates with persistent pulmonary hypertension of the newborn (PPHN).

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Publications

All Publications


  • FXR Agonist INT-747 Upregulates DDAH Expression and Enhances Insulin Sensitivity in High-Salt Fed Dahl Rats PLOS ONE Ghebremariam, Y. T., Yamada, K., Lee, J. C., Johnson, C. L., Atzler, D., Anderssohn, M., Agrawal, R., Higgins, J. P., Patterson, A. J., Boeger, R. H., Cooke, J. P. 2013; 8 (4)
  • FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats. PloS one Ghebremariam, Y. T., Yamada, K., Lee, J. C., Johnson, C. L., Atzler, D., Anderssohn, M., Agrawal, R., Higgins, J. P., Patterson, A. J., Böger, R. H., Cooke, J. P. 2013; 8 (4)

    Abstract

    Genetic and pharmacological studies have shown that impairment of the nitric oxide (NO) synthase (NOS) pathway is associated with hypertension and insulin-resistance (IR). In addition, inhibition of NOS by the endogenous inhibitor, asymmetric dimethylarginine (ADMA), may also result in hypertension and IR. On the other hand, overexpression of dimethylarginine dimethylaminohydrolase (DDAH), an enzyme that metabolizes ADMA, in mice is associated with lower ADMA, increased NO and enhanced insulin sensitivity. Since DDAH carries a farnesoid X receptor (FXR)-responsive element, we aimed to upregulate its expression by an FXR-agonist, INT-747, and evaluate its effect on blood pressure and insulin sensitivity.In this study, we evaluated the in vivo effect of INT-747 on tissue DDAH expression and insulin sensitivity in the Dahl rat model of salt-sensitive hypertension and IR (Dahl-SS). Our data indicates that high salt (HS) diet significantly increased systemic blood pressure. In addition, HS diet downregulated tissue DDAH expression while INT-747 protected the loss in DDAH expression and enhanced insulin sensitivity compared to vehicle controls.Our study may provide the basis for a new therapeutic approach for IR by modulating DDAH expression and/or activity using small molecules.

    View details for DOI 10.1371/journal.pone.0060653

    View details for PubMedID 23593273