- Tissue engineering in flexor tendon surgery: current state and future advances JOURNAL OF HAND SURGERY-EUROPEAN VOLUME 2014; 39 (1): 71-78
"Click" and Olefin Metathesis Chemistry in Water at Room Temperature Enabled by Biodegradable Micelles.
Journal of chemical education
2013; 90 (11)
The two laboratory reactions focus on teaching several concepts associated with green chemistry. Each uses a commercial, nontoxic, and biodegradable surfactant, TPGS-750-M, to promote organic reactions within the lipophilic cores of nanoscale micelles in water. These experiments are based on work by K. Barry Sharpless (an azide-alkyne "click" reaction) and Robert Grubbs (an olefin cross-metathesis reaction); both are suitable for an undergraduate organic laboratory. The copper-catalyzed azide-alkyne [3+2] cycloaddition of benzyl azide and 4-tolylacetylene is very rapid: the triazole product is readily isolated by filtration and is characterized by thin-layer chromatography and melting point analysis. The ruthenium-catalyzed olefin cross-metathesis reaction of benzyl acrylate with 1-hexene is readily monitored by thin-layer chromatography and gas chromatography. The metathesis experiment comparatively evaluates the efficacy of a TPGS-750-M/water medium relative to a traditional reaction performed in dichloromethane (a common solvent used for olefin metathesis).
View details for DOI 10.1021/ed300893u
View details for PubMedID 24324282
CuH-Catalyzed Enantioselective 1,2-Reductions of alpha,beta-Unsaturated Ketones
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
2010; 132 (23): 7852-?
The first study on a general technology for arriving at valued nonracemic allylic alcohols using asymmetric ligand-accelerated catalysis by copper hydride is described.
View details for DOI 10.1021/ja102689e
View details for Web of Science ID 000278717700015
View details for PubMedID 20481528
COMPARATIVE EFFECTIVENESS FOR BARIATRIC SURGERY: CARDIAC RISK FACTOR REDUCTION
ELSEVIER SCIENCE INC. 2013: E1425-E1425
View details for Web of Science ID 000316555201530