Bio

Bio


My research focus involves the application of modern genomics to unravel complex human diseases and promote health. By integrating large-scale human genetic association data with multi-omic profiling and functional models, my work seeks to better understand causal disease mechanisms. Recent efforts involve the discovery of regulatory variants associated with coronary artery disease (CAD) linked to changes in chromatin structure and gene expression in primary vascular cells and tissues. This work encompasses genomics, epigenomics, transcriptomics and the development and application of robust and integrative computational pipelines. We are currently mapping differential allele-specific chromatin states and gene expression in large cohorts using various statistical frameworks. Ultimately these approaches will shed light on the functions and interactions of common regulatory variants, as well as hierarchical patterns of transcription factor binding, chromatin accessibility, and nucleosome positions in different environments. We are applying site-specific genomic targeting in inducible pluripotent stem cells (iPSC) and animal models to further close the gap between associations and disease-relevant phenotypes. I currently maintain a unique biobank of vascular tissues from explanted donor hearts. I am also involved with developing specialized curricula in genomic medicine for both medical students and practicing physicians.