Jieun Lee, PhD is a research associate in the Orthopaedic Surgery Department at Stanford University School of Medicine.
Dr. Lee earned her PhD degree at Yonsei University in Seoul, Korea. In her most significant scientific accomplishments as a PhD student, she elucidated the therapeutic potential of pancreatic progenitor cells, demonstrating how GLP-1-expressing adult pancreatic precursor cells reverse diabetes in STZ-induced diabetic rats (Lee et al., Stem Cells and Development 2009).
Dr. Lee continued stem cell research as a postdoctoral fellow at Stanford University where she lead a project generating safe and efficient human inducible pluripotent stem cells (iPSCs) from somatic cells (Yang et al., Protein Expression Purification, 2011 and Yang et al., Biotechnology Bioengineering, 2009) in John Cooke’s lab in the Department of Cardiovascular Medicine. In her most significant scientific accomplishments as a postdoc, firstly, she found the activation of innate immunity via Toll-like receptor 3 (TLR3) is required for nuclear reprogramming (Lee et al., Cell 2012). It was the first discovery to provide insight on the role of inflammatory mechanism in reprogramming, which has subsequently applied this mechanism to convert human fibroblasts into functional endothelial cells by activating TLR3 (Sayed et al., Circulation 2014).
Currently in Nidhi Bhutani's lab in the Department of Orthopaedic Surgery at Stanford, Dr. Lee has developed an efficient and well-defined chondrogenic differentiation protocol from human iPSCs to generate cartilage tissue in perspective of clinical application for Osteoarthritis (OA) patients and focal cartilage defects (Lee et al., The FASEB J 2015).
Honors & Awards
Scholarship/Grant from Brain Korea 21 Project, Yonsei University, Korea (2000-2006)
Postdoctoral fellowship award, TRDRP, University of California (2009)
Junior Investigator Poster Award, International Society for Stem Cell Research (ISSCR) (2012)