How Does the Xenopus laevis Embryonic Cell Cycle Avoid Spatial Chaos?
2015; 12 (5): 892-900
Effects of inhomogeneities and drift on the dynamics of temporal solitons in fiber cavities and microresonators
2014; 22 (25): 30943-30954
Spatial trigger waves: positive feedback gets you a long way
MOLECULAR BIOLOGY OF THE CELL
2014; 25 (22): 3486-3493
Third-order chromatic dispersion stabilizes Kerr frequency combs
2014; 39 (10): 2971-2974
Theoretical studies have shown that a deterministic biochemical oscillator can become chaotic when operating over a sufficiently large volume and have suggested that the Xenopus laevis cell cycle oscillator operates close to such a chaotic regime. To experimentally test this hypothesis, we decreased the speed of the post-fertilization calcium wave, which had been predicted to generate chaos. However, cell divisions were found to develop normally, and eggs developed into normal tadpoles. Motivated by these experiments, we carried out modeling studies to understand the prerequisites for the predicted spatial chaos. We showed that this type of spatial chaos requires oscillatory reaction dynamics with short pulse duration and postulated that the mitotic exit in Xenopus laevis is likely slow enough to avoid chaos. In systems with shorter pulses, chaos may be an important hazard, as in cardiac arrhythmias, or a useful feature, as in the pigmentation of certain mollusk shells.
View details for DOI 10.1016/j.celrep.2015.06.070
View details for Web of Science ID 000358999800016
View details for PubMedID 26212326