Clinical Focus

  • Obstetrics
  • Obstetrics and Gynecology

Academic Appointments

Administrative Appointments

  • Perinatal and Pediatric Ethics Committee, Stanford/LPCH (2004 - Present)
  • Clinician Educator Appointments and Promotion Committee, Stanford University (2008 - Present)
  • Physician IT Liaison, Division of MFM, Stanford University (2006 - Present)
  • Medical Director, Stanford/LPCH Perinatal Diagnostic Center at Santa Cruz, CA, Lucile Packard Children's Hospital (2005 - Present)
  • Director, OB/GYN Residency Program, Chattanooga Unit of the College of Medicine (1997 - 1999)
  • Chairman, Committee on Academic Appointments and Promotions, Chattanooga Unit of the College of Medicine (1992 - 1998)
  • Chairman, Research Committee, Department of OB/GYN, Chattanooga Unit of the College of Medicine (1989 - 1999)
  • Vice Chairman, Department of OB/GYN, Chattanooga Unit of the College of Medicine (1988 - 1997)
  • Director, Division of Maternal/Fetal Medicine, Chattanooga Unit of the College of Medicine (1986 - 1999)
  • Chair, Perinatal Care Sub-Committee, South-east Tennessee Regional Health Council, State of Tennessee Perinatal Advisory Program (1996 - 2000)

Honors & Awards

  • Rural Prenatal Care Improvement Program Award, State of Tennessee Office of Health Access, Community Initiative Program (1998-2000)
  • Rural Prenatal Nurse Education Grant, March of Dimes (1994-1999)
  • Invaluable Contributions to the Perinatal Cause in Tennessee, Tennessee Perinatal Association (1994)
  • The Baroness Award for Teaching excellence, University of Tennessee (1989)
  • Best Poster award, Society of Perinatal Obstetricians (1984)

Professional Education

  • Board Certification: Obstetrics and Gynecology, American Board of Obstetrics and Gynecology (1986)
  • Board Certification: Maternal and Fetal Medicine, American Board of Obstetrics and Gynecology (1987)
  • Fellowship:University of Tennessee (1985) TN
  • Residency:Medical College of Ohio (1976) OH
  • Internship:Genesys Regional Medical Center-Health Park (1973) MI
  • Medical Education:Tehran University School of Medicine (1969)
  • MD, Tehran University, Medicine (1969)

Research & Scholarship

Current Research and Scholarly Interests

Non-diabetic pregnant women who had episodes of blood glucose excursions had larger babies. An expanded study is on the way to measure the effect of blood glucose excursions on rates of operative deliveries.

We used a new pyrosequencing technique to identify a comprehensive list of vaginal microflora in uncomplicated pregnancies. This catalog can aid future research on effects of vaginal flora on pregnancy complications.

We compared a novel dosing of misoprostol administered orally in a two-step dose to traditional mono-dose vaginal route and found out that patients have a higher satisfaction rate, lower complication rate, and have a lower cesarean delivery rate on oral medication.

Clinical Trials

  • Pedometer Use to Prevent Excessive Pregnancy Weight Gain in Overweight Women Not Recruiting

    The purpose of this study is to evaluate pedometer use by overweight women during pregnancy. The study will show if a pedometer will help women to limit weight gain during pregnancy. It will also show if it there are other benefits such as decreased diabetes, decreased high blood pressure, decreased rates of cesarean section, and decreased complications for the baby.

    Stanford is currently not accepting patients for this trial. For more information, please contact Susan Crowe, MD, (650) 498 - 4069.

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  • Correlation of Continuous Glucose Monitoring and Glucose Tolerance Testing With Pregnancy Outcomes Not Recruiting

    Diabetic pregnant patients are at risk for adverse pregnancy outcomes, including larger than expected fetuses and unplanned operative deliveries, due to elevated blood glucose levels. the one-hour glucola test is currently used to screen pregnant patients for gestational diabetes. This involves ingesting a 50-gram glucose load, followed by a blood test one hour later. We wish to compare 7-day continuous glucose monitoring to the one-hour glucola test, and determine which one correlates better with adverse pregnancy outcomes as well as which one more accurately identifies patients at risk for adverse pregnancy outcomes.

    Stanford is currently not accepting patients for this trial. For more information, please contact Sung Joyce, (650) 804 - 5956.

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  • Effects of Oral Probiotic Supplementation on Group B Strep (GBS) Rectovaginal Colonization in Pregnancy Recruiting

    The investigators wish to determine if oral probiotic supplementation during the second half of pregnancy decreases maternal GBS recto-vaginal colonization at 35-37 weeks' gestational age, thereby decreasing need for maternal antibiotic administration at time of labor. The importance of this study is that it may offer a safer alternative to antibiotic treatment of group B Streptococcus (GBS) colonized pregnant women.

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  • Continuous Glucose Monitoring in Pregnant Women Undergoing Betamethasone Therapy Not Recruiting

    We hope to clarify how betamethasone affects glucose levels in the mother in the days after receiving the drug. This understanding will hopefully allow us to better anticipate the risk of maternal hyperglycemia and therefore establish more appropriate monitoring of maternal glucose to prevent maternal and neonatal complications of hyperglycemia.

    Stanford is currently not accepting patients for this trial. For more information, please contact Yasser El-Sayed, (650) 723 - 3198.

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2014-15 Courses


Journal Articles

  • Continuous Glucose Monitoring During Pregnancy in Women With Polycystic Ovary Syndrome OBSTETRICS AND GYNECOLOGY Sung, J. F., Taslimi, M. M., El-Sayed, Y. Y. 2012; 119 (2): 383-384

    View details for Web of Science ID 000299604300035

    View details for PubMedID 22270301

  • Ultrasound estimation of fetal weight in small for gestational age pregnancies JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE Blumenfeld, Y. J., Lee, H. C., Pullen, K. M., Wong, A. E., Pettit, K., Taslimi, M. M. 2010; 23 (8): 790-793


    Approximately half of small for gestational age (SGA) cases are due to maternal or fetal pathology, and may result in significant neonatal morbidity and mortality. The estimated fetal weight (EFW) measurement is the cornerstone of ultrasonographic findings when diagnosing and managing SGA pregnancies. Our objective was to determine the ultrasound accuracy of EFW in SGA pregnancies.A retrospective chart review was performed of all pregnancies complicated by SGA from a single institution (Stanford University) over a 2-year-period (2004-2006). SGA was defined as EFW < or = 10%. 98 neonates whose last ultrasound for EFW occurred within 7 days of delivery were included in the study. The absolute differences between the EFW and birthweight (BW) were analyzed, and the absolute percent errors were calculated as (EFW - BW)/BW x 100. The mean absolute differences and mean absolute percent errors were analyzed across all gestational ages (GA) and EFWs using one-way analysis of variance.The mean absolute percent error for the entire cohort was 8.7% (+/-6.3%). There was no statistically significant difference in the mean absolute percent error across all GAs (<32 weeks, 32-36 weeks, >36 weeks), and EFWs (<1500 g, 1500-2000 g, >2000 g).Ultrasound measurement of EFW in SGA pregnancies is consistent across all GAs and EFW measurements.

    View details for DOI 10.3109/14767050903387052

    View details for Web of Science ID 000280592200006

    View details for PubMedID 19968588

  • Concealed maternal blood glucose excursions correlate with birth weight centile J Diabetes Sci Technol Taslimi MM, Navabi K, Acosta R, Helmer A, El-Sayed YY 2008; 2 (3): 456-460
  • Complications of Labor and Delivery. Cambridge University Press Fetal and Neonatal Brain Injury, 4th edition Yair Blumenfeld, M Mark Taslimi 2008; In press
  • Stercoral Perforation of the Colon With Favorable Pregnancy Outcome Obstet Gynecol Sung JF, Salvay HB, Hansman MF, Taslimi 2008; In press
  • Variation in Infant Birth Weight: Socioeconomic Factors Versus Medical Conditions Journal of Health & Human Services Administration Hunter, G., Taslimi, MM 2008; 31, 2: 198-222
  • Obstetric Surgery Anesthesiologists Manual of Surgical Procedures. Lippincott Williams & Wilkins M. Mark Taslimi, Yasser El-Sayed 2008; In press
  • Bacterial flora-typing with targeted, chip-based Pyrosequencing BMC MICROBIOLOGY Sundquist, A., Bigdeli, S., Jalili, R., Druzin, M. L., Waller, S., Pullen, K. M., El-Sayed, Y. Y., Taslimi, M. M., Batzoglou, S., Ronaghi, M. 2007; 7


    The metagenomic analysis of microbial communities holds the potential to improve our understanding of the role of microbes in clinical conditions. Recent, dramatic improvements in DNA sequencing throughput and cost will enable such analyses on individuals. However, such advances in throughput generally come at the cost of shorter read-lengths, limiting the discriminatory power of each read. In particular, classifying the microbial content of samples by sequencing the < 1,600 bp 16S rRNA gene will be affected by such limitations.We describe a method for identifying the phylogenetic content of bacterial samples using high-throughput Pyrosequencing targeted at the 16S rRNA gene. Our analysis is adapted to the shorter read-lengths of such technology and uses a database of 16S rDNA to determine the most specific phylogenetic classification for reads, resulting in a weighted phylogenetic tree characterizing the content of the sample. We present results for six samples obtained from the human vagina during pregnancy that corroborates previous studies using conventional techniques.Next, we analyze the power of our method to classify reads at each level of the phylogeny using simulation experiments. We assess the impacts of read-length and database completeness on our method, and predict how we do as technology improves and more bacteria are sequenced. Finally, we study the utility of targeting specific 16S variable regions and show that such an approach considerably improves results for certain types of microbial samples. Using simulation, our method can be used to determine the most informative variable region.This study provides positive validation of the effectiveness of targeting 16S metagenomes using short-read sequencing technology. Our methodology allows us to infer the most specific assignment of the sequence reads within the phylogeny, and to identify the most discriminative variable region to target. The analysis of high-throughput Pyrosequencing on human flora samples will accelerate the study of the relationship between the microbial world and ourselves.

    View details for DOI 10.1186/1471-2180-7-108

    View details for Web of Science ID 000253968300001

    View details for PubMedID 18047683

  • Gestational Diabetes After Delivery, Short-term Management and Long-term Risks Diabetes Care, John L Kitzmiller, Leona Dang-Kilduff, M. Mark Taslimi 2007; 30 S2: S225-S235
  • Detection of sonographic markers of fetal aneuploidy depends on maternal and fetal characteristics JOURNAL OF ULTRASOUND IN MEDICINE Taslimi, M. M., Acosta, R., Chueh, J., Hudgins, L., Hunter, K., Druzin, M. L., Chitkara, U. 2005; 24 (6): 811-815


    The purpose of this study was to determine factors that influence the detection rate of sonographic markers of fetal aneuploidy (SMFA).We reviewed the sonographic images of 160 consecutive second-trimester trisomic fetuses for the presence of SMFA, either structural anomalies or sonographic soft markers.One hundred forty-nine (93.1%) records were complete and analyzed; 78 cases (52.3%) were identified with 1 or more SMFA. Sonographic markers of fetal aneuploidy were detected in 42.7%, 75.0%, and 90.9% of trisomies 21, 18, and 13, respectively (P<.005). The detection rate of SMFA had a positive linear correlation with gestational age (adjusted R(2)=0.64; P<.002). Sonographic markers of fetal aneuploidy were detected in 43.7% of fetuses of less than 18.0 weeks' gestation and 64.5% of fetuses of 18.0 weeks' gestation or greater (likelihood ratio=6.4; P<.01). Sonographic markers of fetal aneuploidy were detected in 23.5% of patients with suboptimal image quality versus 58.3% of the others (likelihood ratio=7.5; P<.05). The rate of structural malformation was similar between the male and female fetuses, whereas that of soft markers was 49.4% in male and 30.0% in female fetuses (odds ratio=2.3; range, 1.2-4.5; P<.02). Factor analysis showed that some soft markers and some structural anomalies tended to appear together.The type of fetal trisomy, gestational age, sex, and quality of images influence the detection rate of SMFA. The highest detection rate for SMFA in the second trimester is at or above 18 weeks' gestational age. Certain markers are detected in clusters. These findings may explain, in part, the variability in reported rates of detection of SMFA among trisomic fetuses. These findings need to be prospectively tested in the general population of pregnancies for applicability to sonographic risk calculations for fetal trisomies.

    View details for Web of Science ID 000229461900009

    View details for PubMedID 15914685

  • Prospective randomized clinical trial of inpatient cervical ripening with stepwise oral misoprostol vs vaginal misoprostot AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY Colon, I., Clawson, K., Hunter, K., Druzin, M. L., Taslimi, M. M. 2005; 192 (3): 747-752


    The purpose of this study was to compare the efficacy and safety of stepwise oral misoprostol vs vaginal misoprostol for cervical ripening before induction of labor.Two hundred and four women between 32 to 42 weeks of gestation with an unfavorable cervix (Bishop score < or = 6) and an indication for labor induction were randomized to receive oral or vaginal misoprostol every 4 hours up to 4 doses. The oral misoprostol group received 50 microg initially followed by 100 microg in each subsequent dose. The vaginal group received 25 microg in each dose. The primary outcome was the interval from first misoprostol dose to delivery. Patient satisfaction and side effects were assessed by surveys completed after delivery.Ninety-three (45.6%) women received oral misoprostol; 111 (54.4%) received vaginal misoprostol. There was no difference in the average interval from the first dose of misoprostol to delivery in the oral (21.1 + 7.9 hrs) and vaginal (21.5 + 11.0 hrs, P = NS) misoprostol groups. The incidence of hyperstimulation in the oral group was 2.2% vs 5.4% in the vaginal group, P = NS. Eighteen patients in the oral group (19.4%) and 36 (32.4%) in the vaginal group underwent cesarean section (P < .05). This difference was attributed to better tolerance of more doses of misoprostol by the women in the oral group. There was no difference in side effects (nausea, vomiting, diarrhea, shivering) between groups. Fourteen percent of women in the vaginal group versus 7.5% in the oral group were dissatisfied with the use of misoprostol (P = NS).Stepwise oral misoprostol (50 microg followed by 100 microg) appears to be as effective as vaginal misoprostol (25 microg) for cervical ripening with a low incidence of hyperstimulation, no increase in side effects, a high rate of patient satisfaction, and is associated with a lower cesarean section rate.

    View details for DOI 10.1016/j.ajog.2004.12.051

    View details for Web of Science ID 000227477600014

    View details for PubMedID 15746667

  • Detection of Sonographic Markers of Fetal Aneuploidy is Dependent on Maternal and Fetal Characteristics J. Ultrasound Med M. Mark Taslimi, Reinaldo Acosta, Jane Chueh, Louanne Hudgins, Kennith Hunter, Maurice L. Druzin, Usha Chitkara 2005; 24: 811-815
  • Vaginal versus ultrasound examination of fetal occiput position during the second stage of labor AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY Chou, M. R., Kreiser, D., Taslimi, M. M., Druzin, M. L., El-Sayed, Y. Y. 2004; 191 (2): 521-524


    The purpose of this study was to determine whether ultrasonography is more accurate than vaginal examination in the determination of fetal occiput position in the second stage of labor.Eighty-eight patients in the second stage of labor were evaluated by vaginal examination and by combined transabdominal and transperineal ultrasound examination to determine occiput position. These predictions of position were compared with the actual delivery position at vaginal delivery after spontaneous restitution or at cesarean delivery. Different examiners performed the vaginal examinations and the ultrasound examinations. Each examiner was blinded to the determination of the other examiner.Vaginal examination determined fetal occiput position correctly 71.6% of the time; ultrasound examination determined fetal occiput position correctly 92.0% of the time (P=.018).Ultrasound examination is more accurate than vaginal examination in the diagnosis of fetal occiput position in the second stage of labor.

    View details for DOI 10.1016/j.ajog.2004.01.029

    View details for Web of Science ID 000203976500020

    View details for PubMedID 15343230

  • Doppler Ultrasonography in Assessment of Fetal Well-being Online Journal of The American Academy of Pediatrics Taslimi MM 2004; 5, 6
  • Obstetric Surgery Anesthesiologists Manual of Surgical Procedures. Lippincott Williams & Wilkins M. Mark Taslimi, Yasser El-Sayed 2004
  • Hamilton county physicians' experience with managed care. Tennessee medicine : journal of the Tennessee Medical Association Taslimi, M. M., Miller, P. E., HICKS, W. H. 2000; 93 (4): 133-135


    Widespread physician participation in managed care over the last several years prompted this survey of the members of the Medical Society of Chattanooga and Hamilton County.A 36-item questionnaire was mailed to all members of the Medical Society.Ninety-six responses from solo practitioners and groups representing 325 physicians were analyzed. More than 80% of respondents believed that managed care has affected the quality of patient care negatively and 71.8% believed managed care policies have compromised their patient care. More importantly, 90% said insurers have not secured their input in policy development. Referral processes were regarded as cumbersome or impossible by 78.2%. Regression analysis showed a significant relation between issues of too much managed care control, cumbersome referral processes, and physicians' opinion on impact of managed care on quality of patient care.Physician dissatisfaction with managed care in Hamilton County appears widespread and is mainly related to issues of too much managed care control over daily patient care, which physicians feel results in compromised quality of patient care.

    View details for PubMedID 10754803

  • Recurrent Pancreatitis in Early Pregnancy. Southern Medical Journal DeVersa R, Panda M, Schmitt C, Taslimi MM 1999; S92: S54
  • Rupture Spontané¬e du Foie Durant la rossesse et le Post-Partum: L'envelopppement Hémostatique: Une Technique Originale Pour Une Pathologie Exceptionnelle La Revue du Practicien Gynécologie et Obstétrique Rittenberry AB, Arnold, CL, Taslimi, MM 1998; 18: 12-13
  • Contribution of consultants to care of compromised pregnancies JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION Bird, J. S., Taslimi, M. M., GONZALES, A. R., Duggan, M. 1996; 88 (2): 97-100


    Obstetricians often seek consultative services of other specialists in the management of compromised pregnancies. However, the extent of such consultations and the contribution of these consultants have not been addressed in the literature. This study is addresses the contribution of consultants to the care of complicated pregnancies at a tertiary care center. During the 2 1/2 years of this retrospective study, 2263 antepartum admissions were made for pregnancy complications. One hundred sixty-six of those patients were hospitalized 176 times and were treated by one or more consulting physicians for a consultation rate of 7.8%. Eighteen specialties were consulted, including 54 (32%) consultations from maternal fetal medicine, 44 (24%) from internal medicine, 28 (16%) from general surgery, and 22 (12%) from endocrinology. Of the initial admission diagnoses, 87.9% were confirmed and 46 new diagnoses were made by the consultants. A significant positive correlation was noted between the number of consultants, maternal length of hospital stay, and maternal hospitalization cost.

    View details for Web of Science ID A1996TV06600010

    View details for PubMedID 8776065

  • Capitation: A Win-Win Proposition Iranian American Medical Association Journal Taslimi MM, Nadjibi-Afshar P 1996; 2, 5: 32-33
  • Teenage Pregnancy Anesthetic and Obstetric management of High-Risk Pregnancy, Mosby-Year Book Inc. St. Louis Monica Jones, M. Mark Taslimi 1996
  • AIDS in Pregnancy Tennessee Perinatal Association Newsletter Taslimi, M.M.: 1996; March
  • Prenatal Detection of Short Arm Deletion and Isochromosome 18 formation Investigated by Molecular Techniques J Med Genet Qumsiyeh M.B., Tomasi A., Taslimi, MM 1995; 32: 991-993


    Preeclampsia has been frequently misdiagnosed as an entity unrelated to pregnancy, with resultant delay in appropriate management. In the case presented here, severe preeclampsia complicated by hemolysis, elevated liver enzymes, and low platelet count ("HELLP syndrome") in a 32-week twin gestation was misdiagnosed as acute appendicitis. Delay in diagnosis and an unnecessary appendectomy resulted in loss of one of the fetuses.

    View details for Web of Science ID A1994PR08700026

    View details for PubMedID 7973910

  • Entwined amniotic band and umbilical cords in a diamniotic twin gestation. Journal of the Tennessee Medical Association Taslimi, M. M. 1994; 87 (1): 5-6

    View details for PubMedID 8145558

  • Perinatal Network: An innovative approach to improve access to care Tennessee Perinatal Association Newsletter Taslimi MM, Barnett F 1994; 4: 11
  • Permanent resolution of severe second trimester oligohydramnios after transabdominal amnioinfusion. Journal of the Tennessee Medical Association Olsen, M. E., Taslimi, M. M. 1993; 86 (1): 7-8

    View details for PubMedID 8455384

  • Malignant mixed müllerian tumor of the fallopian tube of the heterologous type. Journal of the Tennessee Medical Association Moore, D. T., Taslimi, M. M., KOSANOVICH, M. 1992; 85 (11): 513-514

    View details for PubMedID 1331613

  • Non-Hodgkin's lymphoma in pregnancy: a diagnostic dilemma. Case report and review of the literature. Journal of the Tennessee Medical Association Moore, D. T., Taslimi, M. M. 1992; 85 (10): 467-469

    View details for PubMedID 1434609

  • Evolution of cervical cytopathology associated with human papilloma virus infection during pregnancy Journal of Clinical Practice in Sexuality Taslimi MM, Suggs CL, Molina LK 1992; 8: 7-11
  • Bendaggio Emostatico in Caso di Rottura Del Fegato Nel Post Partum: Due Casi Search Your Colleague's Practice on Obstetrics & Gynaecology Rittenberry, A., Arnold, CL, Taslimi, MM 1992; 1: 10-11
  • Multi-agent chemotherapy in a case of non-Hodgkin's lymphoma in second trimester of pregnancy. Journal of the Tennessee Medical Association Moore, D. T., Taslimi, M. M. 1991; 84 (9): 435-436

    View details for PubMedID 1921384



    A variety of surgical techniques with variable success rates have been reported in the management of the spontaneously ruptured liver in pregnancy. We managed two cases of postpartum ruptured liver by wrapping the liver in hemostatic material. Hemostatic encapsulation effectively controlled massive bleeding of ruptured livers in two postpartum patients.

    View details for Web of Science ID A1991GG13600041

    View details for PubMedID 1892199



    Captopril is an inhibitor of angiotensin I converting enzyme and is used for treating intractable chronic hypertension. However, the use of captopril during pregnancy is limited because of reported fetal and neonatal side effects. This study explored the efficacy of sublingual captopril in postpartum management of severe preeclampsia. Captopril controlled the systolic and diastolic pressures within normal range in two patients. The other three patients responded moderately and were switched to hydralazine, clonidine, or nifedipine after 12 hours. The systolic and diastolic pressures of these three patients remained moderately elevated over the 24-hour duration of the study while their pulse rates increased. Captopril did not significantly increase the pulse rate in any of the patients studied, and no other side effects were noted. All patients had normal pressures at their 2- and 6-week postpartum check-up. We conclude that sublingual captopril may be used safely and effectively in managing postpartum hypertension in patients with severe preeclampsia.

    View details for Web of Science ID A1991GB15600014

    View details for PubMedID 1956084

  • Captopril in severe preeclampsia Journal of National Medical Association Taslimi MM, Harbin AR, Gonzalez-Ruiz A 1991; 83: 721-723
  • Supernumerary ribs and vertebrae in trisomy 9 syndrome. Prenatal diagnosis Taslimi, M. M., GLASS, B. A. 1990; 10 (7): 481-?

    View details for PubMedID 2235910

  • First trimester prenatal treatment and molecular genetic diagnosis of congenital adrenal hyperplasia (21-hydroxylase deficiency) Journal of Clinical Endocrinology & Metabolism Speiser PW, Laforgia N, Pareira J, Whorwood C, White PC, New MI, Crawford C, Kato K, Kahn R, Yang SY, Elias S, Schriock E, Simpson JL, Taslimi M, Najjar J, May S, Mills G 1990; 70: 838-848
  • Short labor in carriers of nephrogenic to diabetes insipidus American Journal of Gynecologic Health Taslimi MM, Billedeaux, LA, Gonzalez-Ruiz A 1990; 4: 5-9


    A national survey was conducted to examine the American obstetricians' approach to management of preterm labor. Multiple-choice questionnaires were mailed to all current members of the Society of Perinatal Obstetricians and 750 randomly selected diplomates of the American College of Obstetricians and Gynecologists. Respondents included 249 members of the Society of Perinatal Obstetricians and 441 fellows of the American College of Obstetricians and Gynecologists. Analysis of the replies reflects wide variations among American obstetricians' criteria to diagnose preterm labor, choice of tocolytic agent, use of amniocentesis, and use of corticosteroids. Significant differences were found between the two groups in many aspects of diagnosis and management of preterm labor. However, the replies reflect a high degree of awareness of and many instances of first hand experience with severe beta-adrenergic therapy complications, including maternal death. These findings emphasize the need for caution in selection of patients for beta-adrenergic tocolytic therapy and judicious use of these agents.

    View details for Web of Science ID A1989AC25900007

    View details for PubMedID 2567573


    View details for Web of Science ID A1988R550700054

    View details for PubMedID 3207137


    View details for Web of Science ID A1986E906400058

    View details for PubMedID 3777067



    During an 8-year period, 112 severe preeclamptic-eclamptic patients with the above syndrome were studied. The incidence of this syndrome was significantly higher in white patients, in patients with delayed diagnosis of preeclampsia and/or delayed delivery, and in multiparous patients. Twenty-six patients had amniocentesis and 16 received epidural anesthetics. There was one maternal bleeding episode associated with epidural anesthetics. The use of steroids in 17 patients did not improve maternal platelet count. The overall perinatal mortality was 367 per 1000 and neonatal morbidity was significant. There were two maternal deaths and two patients with ruptured liver hematoma, and nine had acute renal failure. Thirty-eight percent had intravascular coagulopathy and 20% had abruptio placentae. On follow-up, 44 patients used oral contraceptives without maternal morbidity and 38 patients had 49 subsequent pregnancies. Only one patient had recurrence of the syndrome in subsequent pregnancies. The presence of a "true" syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome) in preeclampsia is associated with poor maternal-perinatal outcome.

    View details for Web of Science ID A1986E138900009

    View details for PubMedID 3529964



    Immunoglobulin G antibodies are the most frequent type of red blood cell isoantibodies. They possess the ability to traverse the placenta and may cause hemolytic disease in newborn infants. Of the four subclasses, IgG1 and IgG3 are effective at binding erythrocytes to monocyte-macrophages and therefore are potentially destructive to erythrocytes. IgG2 and IgG4 are unable to react effectively with receptor sites on phagocytic cells and so are totally inactive relative to hemolysis. IgG subclasses were identified in 22 consecutive isoimmunized antepartum patients. Fifteen patients were subsequently delivered of babies who were either affected by or susceptible to hemolytic disease of the newborn. When maternal antibodies consisted of IgG1 only, hemolytic disease of the newborn developed in four of five cases. When only IgG3 was present, each of two patients developed hemolytic disease of the newborn. In eight cases both IgG1 and IgG3 were present and all the babies were born with hemolytic disease of the newborn. Determination of IgG subclasses might prove to be a useful adjunct in evaluating isoimmunized pregnancies. However, the limited information available does not permit the use of IgG subclasses exclusive of traditional means of diagnosis and management of isoimmunized pregnancies.

    View details for Web of Science ID A1986C836700026

    View details for PubMedID 3717242

  • Maternal and perinatal outcome of conservative management of severe preeclampsia in mid-trimester American Journal of Obstetrics & Gynecology Sibai B, Taslimi M, Abdella T, Brooks T, Spinnato J, Anderson G 1985; 152: 32-37

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