Current Research and Scholarly Interests
My research is focused on developing and evaluating molecular imaging agents to improve the way we diagnose, treat, and understand brain diseases.
In particular, I am interested in imaging neuroinflammation, neurodegeneration, cognitive decline, and neurogenesis using positron emission tomography (PET). Non-invasive PET imaging of these biochemical processes in living, intact, subjects may lead to an enhanced understanding of a range of brain disorders (including Alzheimers disease, multiple sclerosis, and brain injury), ultimately generating effective diagnostic techniques and treatment strategies.
For over a decade, my research has involved designing and developing novel PET radioligands for different neurological targets, including the translocator protein (18kDa) (TSPO). Since TSPO expression reflects microglial activation and neuroinflammation, radioligands for this protein may act as valuable tools for detecting regions of active brain disease before clinical signs manifest. These radioligands may also be used to track disease progression and monitor response to novel therapeutics.