Tumor suppression: p53 alters immune surveillance to restrain liver cancer.
2013; 23 (12): R527-30
The p53 tumor suppressor governs multiple cell-intrinsic programs, including cell-cycle arrest and apoptosis, to curb neoplastic growth. A new study reveals that p53 also acts through a novel non-cell-autonomous mechanism, by stimulating the innate immune system to maintain tissue homeostasis and suppress tumorigenesis.
View details for DOI 10.1016/j.cub.2013.04.076
View details for PubMedID 23787049