Research & Scholarship
Current Research and Scholarly Interests
I am interested in the molecular mechanisms that regulate mitochondrial dynamics. I am using rationally-designed peptide inhibitors to target mitochondrial fission/fusion factors in order to understand the interplay between these factors under normal and stressed cellular conditions.
- Mitochondrial Reactive Oxygen Species at the Heart of the Matter New Therapeutic Approaches for Cardiovascular Diseases CIRCULATION RESEARCH 2015; 116 (11): 1783-1799
Mitochondrial Reactive Oxygen Species at the Heart of the Matter: New Therapeutic Approaches for Cardiovascular Diseases.
2015; 116 (11): 1783-1799
Reactive oxygen species (ROS) have been implicated in a variety of age-related diseases, including multiple cardiovascular disorders. However, translation of ROS scavengers (antioxidants) into the clinic has not been successful. These antioxidants grossly reduce total levels of cellular ROS including ROS that participate in physiological signaling. In this review, we challenge the traditional antioxidant therapeutic approach that targets ROS directly with novel approaches that improve mitochondrial functions to more effectively treat cardiovascular diseases.
View details for DOI 10.1161/CIRCRESAHA.116.305432
View details for PubMedID 25999419