Bio

Honors & Awards


  • NIH T32 Postdoctoral Fellowship, Stanford Cancer Imaging Training (SCIT) (2014)
  • Predoctoral Fellowship Award, University of Connecticut (2014)
  • USA PR, Extraordinary Petition (2013)
  • Doctoral Dissertation Fellowship Award, University of Connecticut (2013)
  • Travel Award, SPIE Photonics West 2013 (2013)
  • Predoctoral Fellowship Award, University of Connecticut (2013)
  • 1st Place, Crow Innovation Prize, University of Connecticut (2012)
  • Predoctoral Fellowship Award, University of Connecticut (2011)

Professional Education


  • Doctor of Philosophy, University of Connecticut (2014)

Stanford Advisors


Publications

Journal Articles


  • Interlaced photoacoustic and ultrasound imaging system with real-time coregistration for ovarian tissue characterization JOURNAL OF BIOMEDICAL OPTICS Alqasemi, U., Li, H., Yuan, G., Kumavor, P., Zanganeh, S., Zhu, Q. 2014; 19 (7)

    Abstract

    Coregistered ultrasound (US) and photoacoustic imaging are emerging techniques for mapping the echogenic anatomical structure of tissue and its corresponding optical absorption. We report a 128-channel imaging system with real-time coregistration of the two modalities, which provides up to 15 coregistered frames per second limited by the laser pulse repetition rate. In addition, the system integrates a compact transvaginal imaging probe with a custom-designed fiber optic assembly for in vivo detection and characterization of human ovarian tissue. We present the coregistered US and photoacoustic imaging system structure, the optimal design of the PC interfacing software, and the reconfigurable field programmable gate array operation and optimization. Phantom experiments of system lateral resolution and axial sensitivity evaluation, examples of the real-time scanning of a tumor-bearing mouse, and ex vivo human ovaries studies are demonstrated.

    View details for DOI 10.1117/1.JBO.19.7.076020

    View details for Web of Science ID 000340490400044

    View details for PubMedID 25069009

  • Indocyanine green enhanced co-registered diffuse optical tomography and photoacoustic tomography JOURNAL OF BIOMEDICAL OPTICS Xu, C., Kumavor, P. D., Alqasemi, U., Li, H., Xu, Y., Zanganeh, S., Zhu, Q. 2013; 18 (12)

    Abstract

    To overcome the intensive light scattering in biological tissue, diffuse optical tomography (DOT) in the near-infrared range for breast lesion detection is usually combined with other imaging modalities, such as ultrasound, x-ray, and magnetic resonance imaging, to provide guidance. However, these guiding imaging modalities may depend on different contrast mechanisms compared to the optical contrast in the DOT. As a result, they cannot provide reliable guidance for DOT because some lesions may not be detectable by a nonoptical modality but may have a high optical contrast. An imaging modality that relies on optical contrast to provide guidance is desirable for DOT. We present a system that combines a frequency-domain DOT and real-time photoacoustic tomography (PAT) systems to detect and characterize deeply seated targets embedded in a turbid medium. To further improve the contrast, the exogenous contrast agent, indocyanine green (ICG), is used. Our experimental results show that the combined system can detect a tumor-mimicking phantom, which is immersed in intralipid solution with the concentrations ranging from 100 to 10 μM and with the dimensions of 0.8 cm × 0.8 cm × 0.6 cm, up to 2.5 cm in depth. Mice experiments also confirmed that the combined system can detect tumors and monitor the ICG uptake and washout in the tumor region. This method can potentially improve the accuracy to detect small breast lesions as well as lesions that are sensitive to background tissue changes, such as the lesions located just above the chest wall.

    View details for DOI 10.1117/1.JBO.18.12.126006

    View details for Web of Science ID 000331706500027

    View details for PubMedID 24343437

Presentations


  • Biodistribution study of 2-nitroimidazole indocyanine green conjugate dye conjugates

    Hypoxia markers in previous studies are categorized by the nitroimidazole family. The nitroimidazole
    derivatives show a superior ability in selectively retaining in hypoxic tissues [1, 2]. Among all
    the imidazole compounds, 2-nitroimidazoles have higher electron affinities and are the most
    commonly used hypoxia markers when labeled with positron emission tomography (PET) radionuclides
    [3,4]. Problems associated with the PET modality, including a limited resolution, high background
    counts, the use of radioactive tracers and high cost for routine clinical use, raise a need ...

    Time Period

    4/26/2014 - Present

    Presented To

    Biomedical Optics

    Location

    FLORIDA

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