Doctor of Philosophy, Karolinska Institutet (2011)
Anne Brunet, Postdoctoral Faculty Sponsor
Aging is accompanied by the functional decline of cells, tissues, and organs, as well as a striking increase in a wide range of diseases. The reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) opens new avenues for the aging field and has important applications for therapeutic treatments of age-related diseases. Here we review emerging studies on how aging and age-related pathways influence iPSC generation and property. We discuss the exciting possibility that reverting to a pluripotent stem cell stage erases several deficits associated with aging and offers new strategies for rejuvenation. Finally, we argue that reprogramming provides a unique opportunity to model aging and perhaps exceptional longevity.
View details for DOI 10.1016/j.ceb.2012.10.004
View details for Web of Science ID 000314743100006
View details for PubMedID 23146768