Current Research and Scholarly Interests
My clinical focus is non-Hodgkin's lymphoma (NHL) and am currently conducting clinical trials with novel therapies on these patients. My basic research interest is immunotherapy for lymphoma, with two components: tumor vaccines and allogeneic transplant. For the tumor vaccine, I am working with my colleagues in Oncology to conduct a clinical trial using a CpG-activated tumor vaccine in mantel cell NHL patients who undergo autologous transplantation. The goal is to sensitize the autologous T cells to recognize the malignant lymphoma cells and to expand these tumor-specific T cells immediate after autologous transplant.
Second, I am conducting a study using a novel non-myeloablative preparative regimen prior to allogeneic transplant in patients with mycosis fungoides/Sezary syndrome, a cutaneous T cell NHL. While these patients exhibit little sensitivity to traditional chemotherapy, graft-versus-lymphoma effect provided by allogeneic transplant seems to have an excellent disease control effect. I also use high throughput sequencing technology to assess the minimal residual disease and the immune reconstitution after allogeneic transplant.